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- W2297029149 abstract "Abstract A novel synthetic route to 2,4-functionalized pyrimidines is reported. The approach uses 2-chloro-4-tetrafluorophenoxypyrimidine, that enables sequential palladium catalyzed functionalization at the pyrimidine C-2 position, followed by S N Ar displacement with diverse amines at C-4 . The broad utility of this ‘ C-2 then C-4 ’ functionalization sequence has been demonstrated with a range of cross-coupling partners and amines." @default.
- W2297029149 created "2016-06-24" @default.
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- W2297029149 date "2016-04-01" @default.
- W2297029149 modified "2023-09-27" @default.
- W2297029149 title "2-Chloro-4-tetrafluorophenoxypyrimidine: a versatile reagent for C-2 prior to C-4 functionalizations" @default.
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- W2297029149 doi "https://doi.org/10.1016/j.tetlet.2016.03.057" @default.
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