Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297030250> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2297030250 abstract "Abstract Transcobalamin II (TC II) is essential for cellular uptake of cobalamin. However, the origin of this transport protein is controversial and many organ sources have been suggested. We studied human umbilical vein endothelial cells cultured in vitro. The cells contained TC II (2.3 pmol/10(8) cells) and released progressively increasing amounts of the protein into the surrounding medium during the 3-day incubation period. This release exceeded the starting intracellular content of TC II. In contrast, endothelial cells did not contain or elaborate R binder, the other major circulating binding protein for cobalamin, Cycloheximide inhibited the elaboration of TC II, suggesting that the endothelial cells synthesize the protein. Thrombin, which stimulates tissue plasminogen activator release, did not enhance TC II release, and neither did endotoxin or mellitin. However, thrombin did appear to partially protect TC II release from inhibition by cycloheximide. Among other cells studied, human fibroblasts also released TC II into the incubation medium, while K562 human leukemia cells, ARH-77 and HS Sultan human plasma cell lines, and Raji strain lymphoblasts did not. The data suggest that endothelial cells are an important source of the metabolically crucial TC II." @default.
- W2297030250 created "2016-06-24" @default.
- W2297030250 creator A5057340182 @default.
- W2297030250 creator A5063290032 @default.
- W2297030250 creator A5087358864 @default.
- W2297030250 date "1990-01-01" @default.
- W2297030250 modified "2023-09-30" @default.
- W2297030250 title "Human umbilical vein endothelial cells secrete transcobalamin II" @default.
- W2297030250 cites W1786705555 @default.
- W2297030250 cites W1943863587 @default.
- W2297030250 cites W1977211447 @default.
- W2297030250 cites W1990858659 @default.
- W2297030250 cites W2026682729 @default.
- W2297030250 cites W2039627139 @default.
- W2297030250 cites W2040749670 @default.
- W2297030250 cites W2042052658 @default.
- W2297030250 cites W2050738304 @default.
- W2297030250 cites W2064510906 @default.
- W2297030250 cites W2135189810 @default.
- W2297030250 cites W2157603347 @default.
- W2297030250 cites W2157768631 @default.
- W2297030250 cites W2247712064 @default.
- W2297030250 cites W2272502592 @default.
- W2297030250 cites W2298471771 @default.
- W2297030250 cites W2314887309 @default.
- W2297030250 cites W2342915250 @default.
- W2297030250 cites W2411286637 @default.
- W2297030250 cites W2412426504 @default.
- W2297030250 cites W2476090747 @default.
- W2297030250 doi "https://doi.org/10.1182/blood.v75.1.251.251" @default.
- W2297030250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2104763" @default.
- W2297030250 hasPublicationYear "1990" @default.
- W2297030250 type Work @default.
- W2297030250 sameAs 2297030250 @default.
- W2297030250 citedByCount "7" @default.
- W2297030250 countsByYear W22970302502018 @default.
- W2297030250 countsByYear W22970302502020 @default.
- W2297030250 crossrefType "journal-article" @default.
- W2297030250 hasAuthorship W2297030250A5057340182 @default.
- W2297030250 hasAuthorship W2297030250A5063290032 @default.
- W2297030250 hasAuthorship W2297030250A5087358864 @default.
- W2297030250 hasBestOaLocation W22970302501 @default.
- W2297030250 hasConcept C123012128 @default.
- W2297030250 hasConcept C134018914 @default.
- W2297030250 hasConcept C153911025 @default.
- W2297030250 hasConcept C202751555 @default.
- W2297030250 hasConcept C203014093 @default.
- W2297030250 hasConcept C2777292125 @default.
- W2297030250 hasConcept C2777411675 @default.
- W2297030250 hasConcept C2778128677 @default.
- W2297030250 hasConcept C2779679481 @default.
- W2297030250 hasConcept C3675279 @default.
- W2297030250 hasConcept C54355233 @default.
- W2297030250 hasConcept C55493867 @default.
- W2297030250 hasConcept C81885089 @default.
- W2297030250 hasConcept C86803240 @default.
- W2297030250 hasConcept C89560881 @default.
- W2297030250 hasConceptScore W2297030250C123012128 @default.
- W2297030250 hasConceptScore W2297030250C134018914 @default.
- W2297030250 hasConceptScore W2297030250C153911025 @default.
- W2297030250 hasConceptScore W2297030250C202751555 @default.
- W2297030250 hasConceptScore W2297030250C203014093 @default.
- W2297030250 hasConceptScore W2297030250C2777292125 @default.
- W2297030250 hasConceptScore W2297030250C2777411675 @default.
- W2297030250 hasConceptScore W2297030250C2778128677 @default.
- W2297030250 hasConceptScore W2297030250C2779679481 @default.
- W2297030250 hasConceptScore W2297030250C3675279 @default.
- W2297030250 hasConceptScore W2297030250C54355233 @default.
- W2297030250 hasConceptScore W2297030250C55493867 @default.
- W2297030250 hasConceptScore W2297030250C81885089 @default.
- W2297030250 hasConceptScore W2297030250C86803240 @default.
- W2297030250 hasConceptScore W2297030250C89560881 @default.
- W2297030250 hasLocation W22970302501 @default.
- W2297030250 hasOpenAccess W2297030250 @default.
- W2297030250 hasPrimaryLocation W22970302501 @default.
- W2297030250 hasRelatedWork W1483439037 @default.
- W2297030250 hasRelatedWork W1873268071 @default.
- W2297030250 hasRelatedWork W2019000215 @default.
- W2297030250 hasRelatedWork W2020490392 @default.
- W2297030250 hasRelatedWork W2022692237 @default.
- W2297030250 hasRelatedWork W2028205401 @default.
- W2297030250 hasRelatedWork W2040749670 @default.
- W2297030250 hasRelatedWork W2041564563 @default.
- W2297030250 hasRelatedWork W2045067251 @default.
- W2297030250 hasRelatedWork W2061903796 @default.
- W2297030250 hasRelatedWork W2064209188 @default.
- W2297030250 hasRelatedWork W2069022176 @default.
- W2297030250 hasRelatedWork W2075233240 @default.
- W2297030250 hasRelatedWork W2080551318 @default.
- W2297030250 hasRelatedWork W2103346146 @default.
- W2297030250 hasRelatedWork W2409246332 @default.
- W2297030250 hasRelatedWork W2426329642 @default.
- W2297030250 hasRelatedWork W2503171085 @default.
- W2297030250 hasRelatedWork W3151686651 @default.
- W2297030250 hasRelatedWork W95601366 @default.
- W2297030250 isParatext "false" @default.
- W2297030250 isRetracted "false" @default.
- W2297030250 magId "2297030250" @default.
- W2297030250 workType "article" @default.