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- W2297054512 abstract "MicroRNA (miRNA) plays key roles in post-transcriptional regulations. Recently, a competing endogenous RNA (ceRNA) hypothesis has been proposed that miRNA targets could communicate and regulate each other through titrating shared miRNAs, which provides a new layer of gene regulation. Though a number of ceRNAs playing biological functions have been identified, the ceRNA hypothesis remains controversial. Recent experimental and theoretical studies argued that the modulation of a single RNA species could hardly change the expression level of competing miRNA targets through ceRNA effect under normal physiological conditions. Here, we reviewed a common framework to model miRNA regulations, and summarized the current theoretical and experimental studies for quantitative understanding ceRNA effect. By revisiting a coarse-grained ceRNA model, we proposed that network topology could significantly influence the competing effect and ceRNA regulation at protein level could be much stronger than that at RNA level. We also provided a conditional independent binding equation to describe miRNA relative repression on different target, which could be applied to quantify siRNA off-target effect." @default.
- W2297054512 created "2016-06-24" @default.
- W2297054512 creator A5008093795 @default.
- W2297054512 creator A5014216586 @default.
- W2297054512 creator A5034783238 @default.
- W2297054512 creator A5082583182 @default.
- W2297054512 date "2016-03-01" @default.
- W2297054512 modified "2023-09-23" @default.
- W2297054512 title "A quantitative understanding of microRNA-mediated competing endogenous RNA regulation" @default.
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- W2297054512 doi "https://doi.org/10.1007/s40484-016-0062-5" @default.
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