FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297079083> ?p ?o ?g. }

• W2297079083 abstract "Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly to cancer invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regulate the acquisition of stem-like qualities is an important step towards understanding why patients relapse and towards development of novel therapeutics that specifically target cancer stem cell vulnerabilities. Recent studies identified a role for the aryl hydrocarbon receptor (AHR), an environmental carcinogen receptor implicated in cancer initiation, in normal tissue-specific stem cell self-renewal. These studies inspired the hypothesis that the AHR plays a role in the acquisition of cancer stem cell-like qualities.To test this hypothesis, AHR activity in Hs578T triple negative and SUM149 inflammatory breast cancer cells were modulated with AHR ligands, shRNA or AHR-specific inhibitors, and phenotypic, genomic and functional stem cell-associated characteristics were evaluated. The data demonstrate that (1) ALDH(high) cells express elevated levels of Ahr and Cyp1b1 and Cyp1a1, AHR-driven genes, (2) AHR knockdown reduces ALDH activity by 80%, (3) AHR hyper-activation with several ligands, including environmental ligands, significantly increases ALDH1 activity, expression of stem cell- and invasion/migration-associated genes, and accelerates cell migration, (4) a significant correlation between Ahr or Cyp1b1 expression (as a surrogate marker for AHR activity) and expression of stem cell- and invasion/migration-associated gene sets is seen with genomic data obtained from 79 human breast cancer cell lines and over 1,850 primary human breast cancers, (5) the AHR interacts directly with Sox2, a master regulator of self-renewal; AHR ligands increase this interaction and nuclear SOX2 translocation, (6) AHR knockdown inhibits tumorsphere formation in low adherence conditions, (7) AHR inhibition blocks the rapid migration of ALDH(high) cells and reduces ALDH(high) cell chemoresistance, (8) ALDH(high) cells are highly efficient at initiating tumors in orthotopic xenografts, and (9) AHR knockdown inhibits tumor initiation and reduces tumor Aldh1a1, Sox2, and Cyp1b1 expression in vivo.These data suggest that the AHR plays an important role in development of cells with cancer stem cell-like qualities and that environmental AHR ligands may exacerbate breast cancer by enhancing expression of these properties." @default.
• W2297079083 created "2016-06-24" @default.
• W2297079083 creator A5001352404 @default.
• W2297079083 creator A5017362041 @default.
• W2297079083 creator A5026644077 @default.
• W2297079083 creator A5062891826 @default.
• W2297079083 creator A5062907504 @default.
• W2297079083 creator A5067639617 @default.
• W2297079083 creator A5076515558 @default.
• W2297079083 creator A5080816312 @default.
• W2297079083 creator A5081435946 @default.
• W2297079083 creator A5085175743 @default.
• W2297079083 date "2016-03-16" @default.
• W2297079083 modified "2023-10-17" @default.
• W2297079083 title "The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells" @default.
• W2297079083 cites W1511588128 @default.
• W2297079083 cites W1573746641 @default.
• W2297079083 cites W1589175424 @default.
• W2297079083 cites W1816419917 @default.
• W2297079083 cites W1963965802 @default.
• W2297079083 cites W1964422998 @default.
• W2297079083 cites W1964955179 @default.
• W2297079083 cites W1971386834 @default.
• W2297079083 cites W1974008072 @default.
• W2297079083 cites W1974048771 @default.
• W2297079083 cites W1978785960 @default.
• W2297079083 cites W1979093555 @default.
• W2297079083 cites W1979292119 @default.
• W2297079083 cites W1980714336 @default.
• W2297079083 cites W1985339653 @default.
• W2297079083 cites W1986709105 @default.
• W2297079083 cites W1987112116 @default.
• W2297079083 cites W1989779923 @default.
• W2297079083 cites W1993031861 @default.
• W2297079083 cites W1994930469 @default.
• W2297079083 cites W1995311865 @default.
• W2297079083 cites W1996613294 @default.
• W2297079083 cites W1997847812 @default.
• W2297079083 cites W1998142996 @default.
• W2297079083 cites W2005283959 @default.
• W2297079083 cites W2005895632 @default.
• W2297079083 cites W2014691022 @default.
• W2297079083 cites W2020131167 @default.
• W2297079083 cites W2023316892 @default.
• W2297079083 cites W2023427658 @default.
• W2297079083 cites W2023954166 @default.
• W2297079083 cites W2027604384 @default.
• W2297079083 cites W2029470195 @default.
• W2297079083 cites W2031400039 @default.
• W2297079083 cites W2034639083 @default.
• W2297079083 cites W2036295703 @default.
• W2297079083 cites W2038523895 @default.
• W2297079083 cites W2040511639 @default.
• W2297079083 cites W2040568539 @default.
• W2297079083 cites W2041056824 @default.
• W2297079083 cites W2041566535 @default.
• W2297079083 cites W2041811166 @default.
• W2297079083 cites W2043398720 @default.
• W2297079083 cites W2044166564 @default.
• W2297079083 cites W2044303467 @default.
• W2297079083 cites W2044651251 @default.
• W2297079083 cites W2049423316 @default.
• W2297079083 cites W2050619289 @default.
• W2297079083 cites W2062133273 @default.
• W2297079083 cites W2062187838 @default.
• W2297079083 cites W2062509860 @default.
• W2297079083 cites W2064164438 @default.
• W2297079083 cites W2066254714 @default.
• W2297079083 cites W2068416436 @default.
• W2297079083 cites W2071843955 @default.
• W2297079083 cites W2075683381 @default.
• W2297079083 cites W2076927594 @default.
• W2297079083 cites W2079777624 @default.
• W2297079083 cites W2079827613 @default.
• W2297079083 cites W2080270919 @default.
• W2297079083 cites W2083274861 @default.
• W2297079083 cites W2084334963 @default.
• W2297079083 cites W2086828029 @default.
• W2297079083 cites W2087042197 @default.
• W2297079083 cites W2087900971 @default.
• W2297079083 cites W2089552319 @default.
• W2297079083 cites W2092500220 @default.
• W2297079083 cites W2097893055 @default.
• W2297079083 cites W2102085111 @default.
• W2297079083 cites W2103409364 @default.
• W2297079083 cites W2104666653 @default.
• W2297079083 cites W2105504936 @default.
• W2297079083 cites W2106195342 @default.
• W2297079083 cites W2108244474 @default.
• W2297079083 cites W2108893850 @default.
• W2297079083 cites W2112754168 @default.
• W2297079083 cites W2113916497 @default.
• W2297079083 cites W2120406860 @default.
• W2297079083 cites W2122496261 @default.
• W2297079083 cites W2125987139 @default.
• W2297079083 cites W2127107445 @default.
• W2297079083 cites W2129100666 @default.
• W2297079083 cites W2129214582 @default.
• W2297079083 cites W2133569487 @default.
• W2297079083 cites W2134123270 @default.

• next