FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297114711> ?p ?o ?g. }

• W2297114711 endingPage "336" @default.
• W2297114711 startingPage "330" @default.
• W2297114711 abstract "The AGC kinase family is important cell proliferation and survival. Dysregulation of this family contributes to gastric cancer progression. Here, we evaluated the potential activity of AT13148, a first-in-class multi-AGC kinase inhibitor, against gastric cancer cells. Our results showed that AT13148 exerted potent cytotoxic and anti-proliferative activities against a panel human gastric cancer cell lines (HGC-27, AGS, SNU-601, N87 and MKN-28), possibly via inducing cancer cell apoptotic death. Apoptosis inhibition by the Caspase blockers dramatically attenuated AT13148-caused cytotoxicity against gastric cancer cells. Intriguingly, same AT13148 treatment was not cytotoxic/pro-apoptotic to the non-cancerous human gastric epithelial GEC-1 cells. At the signaling level, AT13148 treatment in gastric cancer cells dramatically suppressed activation of multiple AGC kinases, including Akt (at p-Thr-308), p70S6 kinase (p70S6K), glycogen synthase kinase 3β (GSK-3β) and p90 ribosomal S6 kinase (RSK). Our in vivo studies demonstrated that daily oral gavage of AT13148 at well-tolerated doses significantly inhibited HGC27 xenograft tumor growth in nude mice. AGC activity was also dramatically decreased in AT13148-administrated HGC27 tumors. Therefore, targeting AGC kinases by AT13148 demonstrates superior anti-gastric cancer activity both in vitro and in vivo. The preclinical results of this study support the progression of this molecule into future evaluation as a valuable anti-gastric cancer candidate." @default.
• W2297114711 created "2016-06-24" @default.
• W2297114711 creator A5024298237 @default.
• W2297114711 creator A5040894182 @default.
• W2297114711 creator A5056185090 @default.
• W2297114711 creator A5062665642 @default.
• W2297114711 creator A5070248614 @default.
• W2297114711 creator A5079817705 @default.
• W2297114711 date "2016-09-01" @default.
• W2297114711 modified "2023-09-26" @default.
• W2297114711 title "AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo" @default.
• W2297114711 cites W1980175613 @default.
• W2297114711 cites W1984621921 @default.
• W2297114711 cites W2004478962 @default.
• W2297114711 cites W2015714994 @default.
• W2297114711 cites W2029855107 @default.
• W2297114711 cites W2046584993 @default.
• W2297114711 cites W2066700651 @default.
• W2297114711 cites W2072966188 @default.
• W2297114711 cites W2079926131 @default.
• W2297114711 cites W2087861588 @default.
• W2297114711 cites W2130807572 @default.
• W2297114711 cites W2155228605 @default.
• W2297114711 cites W2166429460 @default.
• W2297114711 cites W2388163742 @default.
• W2297114711 cites W2417439103 @default.
• W2297114711 cites W798382597 @default.
• W2297114711 cites W929310391 @default.
• W2297114711 doi "https://doi.org/10.1016/j.bbrc.2016.01.167" @default.
• W2297114711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26828267" @default.
• W2297114711 hasPublicationYear "2016" @default.
• W2297114711 type Work @default.
• W2297114711 sameAs 2297114711 @default.
• W2297114711 citedByCount "11" @default.
• W2297114711 countsByYear W22971147112017 @default.
• W2297114711 countsByYear W22971147112018 @default.
• W2297114711 countsByYear W22971147112019 @default.
• W2297114711 countsByYear W22971147112020 @default.
• W2297114711 countsByYear W22971147112022 @default.
• W2297114711 countsByYear W22971147112023 @default.
• W2297114711 crossrefType "journal-article" @default.
• W2297114711 hasAuthorship W2297114711A5024298237 @default.
• W2297114711 hasAuthorship W2297114711A5040894182 @default.
• W2297114711 hasAuthorship W2297114711A5056185090 @default.
• W2297114711 hasAuthorship W2297114711A5062665642 @default.
• W2297114711 hasAuthorship W2297114711A5070248614 @default.
• W2297114711 hasAuthorship W2297114711A5079817705 @default.
• W2297114711 hasConcept C121608353 @default.
• W2297114711 hasConcept C126322002 @default.
• W2297114711 hasConcept C150903083 @default.
• W2297114711 hasConcept C154317977 @default.
• W2297114711 hasConcept C182996813 @default.
• W2297114711 hasConcept C184235292 @default.
• W2297114711 hasConcept C185592680 @default.
• W2297114711 hasConcept C190283241 @default.
• W2297114711 hasConcept C202751555 @default.
• W2297114711 hasConcept C207001950 @default.
• W2297114711 hasConcept C502942594 @default.
• W2297114711 hasConcept C55493867 @default.
• W2297114711 hasConcept C71924100 @default.
• W2297114711 hasConcept C75217442 @default.
• W2297114711 hasConcept C86803240 @default.
• W2297114711 hasConcept C95444343 @default.
• W2297114711 hasConcept C96232424 @default.
• W2297114711 hasConcept C98274493 @default.
• W2297114711 hasConceptScore W2297114711C121608353 @default.
• W2297114711 hasConceptScore W2297114711C126322002 @default.
• W2297114711 hasConceptScore W2297114711C150903083 @default.
• W2297114711 hasConceptScore W2297114711C154317977 @default.
• W2297114711 hasConceptScore W2297114711C182996813 @default.
• W2297114711 hasConceptScore W2297114711C184235292 @default.
• W2297114711 hasConceptScore W2297114711C185592680 @default.
• W2297114711 hasConceptScore W2297114711C190283241 @default.
• W2297114711 hasConceptScore W2297114711C202751555 @default.
• W2297114711 hasConceptScore W2297114711C207001950 @default.
• W2297114711 hasConceptScore W2297114711C502942594 @default.
• W2297114711 hasConceptScore W2297114711C55493867 @default.
• W2297114711 hasConceptScore W2297114711C71924100 @default.
• W2297114711 hasConceptScore W2297114711C75217442 @default.
• W2297114711 hasConceptScore W2297114711C86803240 @default.
• W2297114711 hasConceptScore W2297114711C95444343 @default.
• W2297114711 hasConceptScore W2297114711C96232424 @default.
• W2297114711 hasConceptScore W2297114711C98274493 @default.
• W2297114711 hasFunder F4320321001 @default.
• W2297114711 hasIssue "1" @default.
• W2297114711 hasLocation W22971147111 @default.
• W2297114711 hasLocation W22971147112 @default.
• W2297114711 hasOpenAccess W2297114711 @default.
• W2297114711 hasPrimaryLocation W22971147111 @default.
• W2297114711 hasRelatedWork W1528770089 @default.
• W2297114711 hasRelatedWork W1981600545 @default.
• W2297114711 hasRelatedWork W1983855168 @default.
• W2297114711 hasRelatedWork W1998817804 @default.
• W2297114711 hasRelatedWork W2378785636 @default.
• W2297114711 hasRelatedWork W2386538333 @default.
• W2297114711 hasRelatedWork W2386605958 @default.
• W2297114711 hasRelatedWork W2501960686 @default.
• W2297114711 hasRelatedWork W3012168770 @default.

• next