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- W2297151034 abstract "A chemistry for the facile two-component macrocyclization of unprotected peptide isocyanates is described. Starting from peptides containing two glutamic acid γ-hydrazide residues, isocyanates can be readily accessed and cyclized with hydrazides of dicarboxylic acids. The choice of a nucleophilic linker allows for the facile modulation of biochemical properties of a macrocyclic peptide. Four cyclic NYAD-1 analogues were synthesized using the described method and displayed a range of biological activities." @default.
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- W2297151034 date "2016-03-07" @default.
- W2297151034 modified "2023-09-28" @default.
- W2297151034 title "Macrocyclization of Unprotected Peptide Isocyanates" @default.
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- W2297151034 doi "https://doi.org/10.1021/acs.orglett.5b03626" @default.
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