FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297152275> ?p ?o ?g. }

• W2297152275 endingPage "F716" @default.
• W2297152275 startingPage "F705" @default.
• W2297152275 abstract "No therapies have been shown to accelerate recovery or prevent fibrosis after acute kidney injury (AKI). In part, this is because most therapeutic candidates have to be given at the time of injury and the diagnosis of AKI is usually made too late for drugs to be efficacious. Strategies to enhance post-AKI repair represent an attractive approach to address this. Using a phenotypic screen in zebrafish, we identified 4-(phenylthio)butanoic acid (PTBA), which promotes proliferation of embryonic kidney progenitor cells (EKPCs), and the PTBA methyl ester UPHD25, which also increases postinjury repair in ischemia-reperfusion and aristolochic acid-induced AKI in mice. In these studies, a new panel of PTBA analogs was evaluated. Initial screening was performed in zebrafish EKPC assays followed by survival assays in a gentamicin-induced AKI larvae zebrafish model. Using this approach, we identified UPHD186, which in contrast to UPHD25, accelerates recovery and reduces fibrosis when administered several days after ischemia-reperfusion AKI and reduces fibrosis after unilateral ureteric obstruction in mice. UPHD25 and 186 are efficiently metabolized to the active analog PTBA in liver and kidney microsome assays, indicating both compounds may act as PTBA prodrugs in vivo. UPHD186 persists longer in the circulation than UPHD25, suggesting that sustained levels of UPHD186 may increase efficacy by acting as a reservoir for renal metabolism to PTBA. These findings validate use of zebrafish EKPC and AKI assays as a drug discovery strategy for molecules that reduce fibrosis in multiple AKI models and can be administered days after initiation of injury." @default.
• W2297152275 created "2016-06-24" @default.
• W2297152275 creator A5002644615 @default.
• W2297152275 creator A5006686477 @default.
• W2297152275 creator A5009531733 @default.
• W2297152275 creator A5018238937 @default.
• W2297152275 creator A5019011479 @default.
• W2297152275 creator A5024001617 @default.
• W2297152275 creator A5025757528 @default.
• W2297152275 creator A5027713642 @default.
• W2297152275 creator A5038463777 @default.
• W2297152275 creator A5047634622 @default.
• W2297152275 creator A5050726251 @default.
• W2297152275 creator A5061432494 @default.
• W2297152275 creator A5068845663 @default.
• W2297152275 creator A5069699230 @default.
• W2297152275 creator A5087527556 @default.
• W2297152275 creator A5088980863 @default.
• W2297152275 date "2016-04-15" @default.
• W2297152275 modified "2023-10-10" @default.
• W2297152275 title "Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury" @default.
• W2297152275 cites W1967712562 @default.
• W2297152275 cites W1970174538 @default.
• W2297152275 cites W1973215369 @default.
• W2297152275 cites W1974181209 @default.
• W2297152275 cites W1983640477 @default.
• W2297152275 cites W1985069389 @default.
• W2297152275 cites W2008726636 @default.
• W2297152275 cites W2018091219 @default.
• W2297152275 cites W2019442978 @default.
• W2297152275 cites W2021690806 @default.
• W2297152275 cites W2027117428 @default.
• W2297152275 cites W2047621580 @default.
• W2297152275 cites W2052214665 @default.
• W2297152275 cites W2066976865 @default.
• W2297152275 cites W2075596754 @default.
• W2297152275 cites W2079079821 @default.
• W2297152275 cites W2088413454 @default.
• W2297152275 cites W2101524200 @default.
• W2297152275 cites W2115473542 @default.
• W2297152275 cites W2127336805 @default.
• W2297152275 cites W2128324639 @default.
• W2297152275 cites W2132845755 @default.
• W2297152275 cites W2135046321 @default.
• W2297152275 cites W2146081758 @default.
• W2297152275 cites W2147797461 @default.
• W2297152275 cites W2158079337 @default.
• W2297152275 cites W2160005456 @default.
• W2297152275 cites W2167103757 @default.
• W2297152275 cites W2949897611 @default.
• W2297152275 doi "https://doi.org/10.1152/ajprenal.00503.2015" @default.
• W2297152275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4835925" @default.
• W2297152275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26661656" @default.
• W2297152275 hasPublicationYear "2016" @default.
• W2297152275 type Work @default.
• W2297152275 sameAs 2297152275 @default.
• W2297152275 citedByCount "28" @default.
• W2297152275 countsByYear W22971522752016 @default.
• W2297152275 countsByYear W22971522752017 @default.
• W2297152275 countsByYear W22971522752018 @default.
• W2297152275 countsByYear W22971522752019 @default.
• W2297152275 countsByYear W22971522752020 @default.
• W2297152275 countsByYear W22971522752021 @default.
• W2297152275 countsByYear W22971522752022 @default.
• W2297152275 countsByYear W22971522752023 @default.
• W2297152275 crossrefType "journal-article" @default.
• W2297152275 hasAuthorship W2297152275A5002644615 @default.
• W2297152275 hasAuthorship W2297152275A5006686477 @default.
• W2297152275 hasAuthorship W2297152275A5009531733 @default.
• W2297152275 hasAuthorship W2297152275A5018238937 @default.
• W2297152275 hasAuthorship W2297152275A5019011479 @default.
• W2297152275 hasAuthorship W2297152275A5024001617 @default.
• W2297152275 hasAuthorship W2297152275A5025757528 @default.
• W2297152275 hasAuthorship W2297152275A5027713642 @default.
• W2297152275 hasAuthorship W2297152275A5038463777 @default.
• W2297152275 hasAuthorship W2297152275A5047634622 @default.
• W2297152275 hasAuthorship W2297152275A5050726251 @default.
• W2297152275 hasAuthorship W2297152275A5061432494 @default.
• W2297152275 hasAuthorship W2297152275A5068845663 @default.
• W2297152275 hasAuthorship W2297152275A5069699230 @default.
• W2297152275 hasAuthorship W2297152275A5087527556 @default.
• W2297152275 hasAuthorship W2297152275A5088980863 @default.
• W2297152275 hasBestOaLocation W22971522751 @default.
• W2297152275 hasConcept C104317684 @default.
• W2297152275 hasConcept C126322002 @default.
• W2297152275 hasConcept C150903083 @default.
• W2297152275 hasConcept C207001950 @default.
• W2297152275 hasConcept C2776878037 @default.
• W2297152275 hasConcept C2780091579 @default.
• W2297152275 hasConcept C2780472472 @default.
• W2297152275 hasConcept C2780559512 @default.
• W2297152275 hasConcept C2780813843 @default.
• W2297152275 hasConcept C541997718 @default.
• W2297152275 hasConcept C54355233 @default.
• W2297152275 hasConcept C55493867 @default.
• W2297152275 hasConcept C71924100 @default.
• W2297152275 hasConcept C86803240 @default.
• W2297152275 hasConcept C98274493 @default.

• next