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- W2297194954 abstract "In Yoshida sarcoma of rat, 3 to 4 days after transplantation, the frequency of mitosis, change in number in each mitotic phase, and the frequency of chromosome abnormalities in the metaphase and anaphase were observed. ThioTEPA produced a rapid decrease in number of mitotic cells, which were fewest 9 to 12 hr after injection. Thereafter, they gradually increased in number, but did not return to pre-treatment levels, even at 48 hr. Abnormal chromosomes showing signs of stickiness and/or condensation were observed in the metaphase, and chromosome bridges induced by breskage and stickiness of chromosomes appeared in the anaphase. These so-called radiomimetic effects resemble those of x ray. Combined use of thio-TEPA with x rays showed independent effects, though irradiation atfer injection resulted in a stronger effect than injection alone, and irradiation before injection reduced the effect of thio-TEPA. (Absts. Japan. Med., 1: No. 7, 1960.)" @default.
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- W2297194954 date "1959-01-01" @default.
- W2297194954 modified "2023-09-23" @default.
- W2297194954 title "STUDIES ON THE COMBINED EFFECT OF IRRADIATION AND VARIOUS CHEMICALS ON MITOTIC CELLS. XVI. EFFECTS OF COMBINED USE OF X-RAY AND THIO-TEPA ON YOSHIDA SARCOMA" @default.
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