FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297213025> ?p ?o ?g. }

• W2297213025 endingPage "63" @default.
• W2297213025 startingPage "55" @default.
• W2297213025 abstract "Thalassemia is a monogenic hematologic disease that has the highest prevalence globally. In addition, there is complexity of the genetic background associated with a variety of phenotypes presented among patients. Genetic heterogeneity related to fetal hemoglobin (HbF) production has been reported as an influencing phenotypic factor of β-thalassemia (β-thal). Therefore, this study aimed to find the effect of these genetic modifiers, especially in the XmnI locus, rs11886868, rs766432 (BCL11A), and rs9399137 (HBS1L-MYB), among β-thal and HbE/β-thal patients in Indonesia, according to laboratory and clinical outcomes, including HbF levels and clinical scores. This study was also designed to compare these modifying effects among β-thal and HbE/β-thal patients in Indonesia. A total of 189 patients with genotyping of β-thal and HbE/β-thal were included in this study. The erythrocytes index and Hb electrophoresis measurements were calculated using appropriate methods. The severity of β-thal and HbE/β-thal was classified based on the Mahidol score. Polymorphism of the XmnI locus, rs11886868, rs766432 (BCL11A), and rs9399137 (HBS1L-MYB) was determined using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) and amplification refractory mutation system (ARMS) methods. The distributions of minor allele in the XmnI locus, rs11886868, rs766432, and rs9399137 were 14%, 22%, 19% and 18% respectively. The variation allele in the XmnI locus, rs11886868, and rs766432 showed a significant value for modifying HbF and clinical score in HbE/β-thal patients, but rs9399137 did not demonstrate such features. In β-thal patients, however, no correlation was found for any single-nucleotide polymorphisms and clinical appearance. The XmnI locus, rs11886868, and rs766432 have a modifying effect on HbF and clinical score in HbE/β-thal patients in Indonesia, but not in β-thal patients." @default.
• W2297213025 created "2016-06-24" @default.
• W2297213025 creator A5002116011 @default.
• W2297213025 creator A5029350411 @default.
• W2297213025 creator A5046128553 @default.
• W2297213025 creator A5056243327 @default.
• W2297213025 creator A5067479388 @default.
• W2297213025 creator A5081037222 @default.
• W2297213025 creator A5085962603 @default.
• W2297213025 creator A5087363894 @default.
• W2297213025 creator A5088625329 @default.
• W2297213025 date "2016-06-01" @default.
• W2297213025 modified "2023-09-30" @default.
• W2297213025 title "Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances: A study on β-thalassemia and hemoglobin E/β-thalassemia patients in Indonesia" @default.
• W2297213025 cites W1481317450 @default.
• W2297213025 cites W1545225805 @default.
• W2297213025 cites W1944811154 @default.
• W2297213025 cites W1969482851 @default.
• W2297213025 cites W1969724251 @default.
• W2297213025 cites W1984633733 @default.
• W2297213025 cites W1994923329 @default.
• W2297213025 cites W1995241373 @default.
• W2297213025 cites W1998535080 @default.
• W2297213025 cites W1998916828 @default.
• W2297213025 cites W2002413427 @default.
• W2297213025 cites W2004053059 @default.
• W2297213025 cites W2005898133 @default.
• W2297213025 cites W2006186502 @default.
• W2297213025 cites W2008989169 @default.
• W2297213025 cites W2012020901 @default.
• W2297213025 cites W2026938006 @default.
• W2297213025 cites W2035559498 @default.
• W2297213025 cites W2040981306 @default.
• W2297213025 cites W2049584544 @default.
• W2297213025 cites W2052961424 @default.
• W2297213025 cites W2058263094 @default.
• W2297213025 cites W2061406348 @default.
• W2297213025 cites W2070879341 @default.
• W2297213025 cites W2082592747 @default.
• W2297213025 cites W2091710493 @default.
• W2297213025 cites W2091849888 @default.
• W2297213025 cites W2099163399 @default.
• W2297213025 cites W2103189748 @default.
• W2297213025 cites W2103469557 @default.
• W2297213025 cites W2122620918 @default.
• W2297213025 cites W2130887575 @default.
• W2297213025 cites W2136920661 @default.
• W2297213025 cites W2160859576 @default.
• W2297213025 cites W2161143576 @default.
• W2297213025 cites W2578152286 @default.
• W2297213025 cites W3187992181 @default.
• W2297213025 doi "https://doi.org/10.1016/j.hemonc.2016.02.003" @default.
• W2297213025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27009595" @default.
• W2297213025 hasPublicationYear "2016" @default.
• W2297213025 type Work @default.
• W2297213025 sameAs 2297213025 @default.
• W2297213025 citedByCount "33" @default.
• W2297213025 countsByYear W22972130252017 @default.
• W2297213025 countsByYear W22972130252018 @default.
• W2297213025 countsByYear W22972130252019 @default.
• W2297213025 countsByYear W22972130252020 @default.
• W2297213025 countsByYear W22972130252021 @default.
• W2297213025 countsByYear W22972130252022 @default.
• W2297213025 countsByYear W22972130252023 @default.
• W2297213025 crossrefType "journal-article" @default.
• W2297213025 hasAuthorship W2297213025A5002116011 @default.
• W2297213025 hasAuthorship W2297213025A5029350411 @default.
• W2297213025 hasAuthorship W2297213025A5046128553 @default.
• W2297213025 hasAuthorship W2297213025A5056243327 @default.
• W2297213025 hasAuthorship W2297213025A5067479388 @default.
• W2297213025 hasAuthorship W2297213025A5081037222 @default.
• W2297213025 hasAuthorship W2297213025A5085962603 @default.
• W2297213025 hasAuthorship W2297213025A5087363894 @default.
• W2297213025 hasAuthorship W2297213025A5088625329 @default.
• W2297213025 hasBestOaLocation W22972130251 @default.
• W2297213025 hasConcept C104317684 @default.
• W2297213025 hasConcept C126322002 @default.
• W2297213025 hasConcept C135763542 @default.
• W2297213025 hasConcept C172680121 @default.
• W2297213025 hasConcept C180754005 @default.
• W2297213025 hasConcept C2776317666 @default.
• W2297213025 hasConcept C2777799968 @default.
• W2297213025 hasConcept C2777940137 @default.
• W2297213025 hasConcept C2779234561 @default.
• W2297213025 hasConcept C2781217586 @default.
• W2297213025 hasConcept C31467283 @default.
• W2297213025 hasConcept C54355233 @default.
• W2297213025 hasConcept C71924100 @default.
• W2297213025 hasConcept C84597430 @default.
• W2297213025 hasConcept C86803240 @default.
• W2297213025 hasConcept C90924648 @default.
• W2297213025 hasConceptScore W2297213025C104317684 @default.
• W2297213025 hasConceptScore W2297213025C126322002 @default.
• W2297213025 hasConceptScore W2297213025C135763542 @default.
• W2297213025 hasConceptScore W2297213025C172680121 @default.
• W2297213025 hasConceptScore W2297213025C180754005 @default.
• W2297213025 hasConceptScore W2297213025C2776317666 @default.
• W2297213025 hasConceptScore W2297213025C2777799968 @default.

• next