FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297217814> ?p ?o ?g. }

• W2297217814 abstract "Scope Binge consumption of alcohol is an alarming global health problem. Acute ethanol intoxication is characterized by hepatic inflammation and oxidative stress, which could be promoted by gut barrier function alterations. In this study, we have tested the hypothesis of the hepatoprotective effect of rhubarb extract in a mouse model of binge drinking and we explored the contribution of the gut microbiota in the related metabolic effects. Methods and results Mice were fed a control diet supplemented with or without 0.3% rhubarb extract for 17 days and were necropsied 6 h after an alcohol challenge. Supplementation with rhubarb extract changed the microbial ecosystem (assessed by 16S rDNA pyrosequencing) in favor of Akkermansia muciniphila and Parabacteroides goldsteinii . Furthermore, it improved alcohol‐induced hepatic injury, downregulated key markers of both inflammatory and oxidative stresses in the liver tissue, without affecting significantly steatosis. In the gut, rhubarb supplementation increased crypt depth, tissue weight, and the expression of antimicrobial peptides. Conclusions These findings suggest that some bacterial genders involved in gut barrier function, are promoted by phytochemicals present in rhubarb extract, and could therefore be involved in the modulation of the susceptibility to hepatic diseases linked to acute alcohol consumption." @default.
• W2297217814 created "2016-06-24" @default.
• W2297217814 creator A5005606442 @default.
• W2297217814 creator A5019241523 @default.
• W2297217814 creator A5042192451 @default.
• W2297217814 creator A5049509915 @default.
• W2297217814 creator A5054047423 @default.
• W2297217814 creator A5054587826 @default.
• W2297217814 creator A5070336660 @default.
• W2297217814 creator A5074632501 @default.
• W2297217814 date "2016-06-01" @default.
• W2297217814 modified "2023-10-09" @default.
• W2297217814 title "Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota" @default.
• W2297217814 cites W1172305272 @default.
• W2297217814 cites W1432726693 @default.
• W2297217814 cites W1900984136 @default.
• W2297217814 cites W1914049311 @default.
• W2297217814 cites W1919048856 @default.
• W2297217814 cites W1920985532 @default.
• W2297217814 cites W1963957869 @default.
• W2297217814 cites W1975691929 @default.
• W2297217814 cites W1977194186 @default.
• W2297217814 cites W1977475597 @default.
• W2297217814 cites W1978844772 @default.
• W2297217814 cites W1982643977 @default.
• W2297217814 cites W1984167160 @default.
• W2297217814 cites W1990128815 @default.
• W2297217814 cites W1996535102 @default.
• W2297217814 cites W2014185375 @default.
• W2297217814 cites W2016223370 @default.
• W2297217814 cites W2018054151 @default.
• W2297217814 cites W2027968599 @default.
• W2297217814 cites W2033689665 @default.
• W2297217814 cites W2034007873 @default.
• W2297217814 cites W2034801500 @default.
• W2297217814 cites W2038083364 @default.
• W2297217814 cites W2043152022 @default.
• W2297217814 cites W2044238207 @default.
• W2297217814 cites W2044553759 @default.
• W2297217814 cites W2047971738 @default.
• W2297217814 cites W2048853985 @default.
• W2297217814 cites W2050116830 @default.
• W2297217814 cites W2057387707 @default.
• W2297217814 cites W2060637877 @default.
• W2297217814 cites W2066299623 @default.
• W2297217814 cites W2066607113 @default.
• W2297217814 cites W2069653115 @default.
• W2297217814 cites W2077590888 @default.
• W2297217814 cites W2085503158 @default.
• W2297217814 cites W2087051893 @default.
• W2297217814 cites W2094886286 @default.
• W2297217814 cites W2109483752 @default.
• W2297217814 cites W2115496765 @default.
• W2297217814 cites W2120792160 @default.
• W2297217814 cites W2124572106 @default.
• W2297217814 cites W2138986581 @default.
• W2297217814 cites W2144862608 @default.
• W2297217814 cites W2145189896 @default.
• W2297217814 cites W2147790901 @default.
• W2297217814 cites W2150326634 @default.
• W2297217814 cites W2153075279 @default.
• W2297217814 cites W2153350230 @default.
• W2297217814 cites W2155917817 @default.
• W2297217814 cites W2316485179 @default.
• W2297217814 cites W2402937561 @default.
• W2297217814 cites W2416662732 @default.
• W2297217814 cites W2614118501 @default.
• W2297217814 cites W969915667 @default.
• W2297217814 doi "https://doi.org/10.1002/mnfr.201500899" @default.
• W2297217814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26990039" @default.
• W2297217814 hasPublicationYear "2016" @default.
• W2297217814 type Work @default.
• W2297217814 sameAs 2297217814 @default.
• W2297217814 citedByCount "129" @default.
• W2297217814 countsByYear W22972178142016 @default.
• W2297217814 countsByYear W22972178142017 @default.
• W2297217814 countsByYear W22972178142018 @default.
• W2297217814 countsByYear W22972178142019 @default.
• W2297217814 countsByYear W22972178142020 @default.
• W2297217814 countsByYear W22972178142021 @default.
• W2297217814 countsByYear W22972178142022 @default.
• W2297217814 countsByYear W22972178142023 @default.
• W2297217814 crossrefType "journal-article" @default.
• W2297217814 hasAuthorship W2297217814A5005606442 @default.
• W2297217814 hasAuthorship W2297217814A5019241523 @default.
• W2297217814 hasAuthorship W2297217814A5042192451 @default.
• W2297217814 hasAuthorship W2297217814A5049509915 @default.
• W2297217814 hasAuthorship W2297217814A5054047423 @default.
• W2297217814 hasAuthorship W2297217814A5054587826 @default.
• W2297217814 hasAuthorship W2297217814A5070336660 @default.
• W2297217814 hasAuthorship W2297217814A5074632501 @default.
• W2297217814 hasBestOaLocation W22972178142 @default.
• W2297217814 hasConcept C100544194 @default.
• W2297217814 hasConcept C134018914 @default.
• W2297217814 hasConcept C203014093 @default.
• W2297217814 hasConcept C2775941767 @default.
• W2297217814 hasConcept C2776109033 @default.
• W2297217814 hasConcept C2776151105 @default.
• W2297217814 hasConcept C2776175330 @default.
• W2297217814 hasConcept C2776637226 @default.

• next