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- W2297218058 abstract "BackgroundAtrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) belong to a family of hormones that have structural similarities and some biological actions in common, such as natriuresis and vasodilatation. Previous studies have revealed the presence of ANP and BNP in the sheep atrial extract and ANP in the human atrium. The aim of the present study was to compare the hemodynamic effects of the two atrial extracts on blood pressure and hematocrit in anesthetized rats. MethodsHuman and sheep atrial extracts were prepared using saline and acid milieu method. The femoral arteries and jugular veins were cannulated for recording blood pressure and drug administration, respectively. To measure the hematocrit, we collected blood samples from the rats’ eyes at the beginning and once again after 45 minutes of extract administration. ResultThe rats’ mean arterial blood pressure (MAP) was reduced by the sheep atrial extract (p<0.05), whereas the human atrial extract did not have any significant effect on MAP. The hypotensive effect of the sheep atrial extract was higher than that of the human extract (p<0.05). Both extracts increased the rats’ hematocrit significantly (P<0.05). DiscussionThe obtained results suggest that the difference between the hemodynamic effects of the two extracts could be due to the differences between the ANP and BNP clearance, cardiac output fall and the negative feedback inhibition (Iranian Heart Journal 2005; 6 (1,2): 78-82)." @default.
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- W2297218058 date "2005-01-01" @default.
- W2297218058 modified "2023-09-23" @default.
- W2297218058 title "COMPARISON OF THE HEMODYNAMIC EFFECTS OF HUMAN AND SHEEP ATRIAL EXTRACTS IN ANESTHETIZED RATS" @default.
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