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- W2297256877 abstract "Understanding the molecular mechanisms of tumor initiation has significant impact on early cancer detection and intervention. To define the role of KLF4 in pancreatic ductal adenocarcinoma (PDA) initiation, we used molecular biological analyses and mouse models of klf4 gain- and loss-of-function and mutant Kras. KLF4 is upregulated in and required for acinar-to-ductal metaplasia. Klf4 ablation drastically attenuates the formation of pancreatic intraepithelial neoplasia induced by mutant Kras(G12D), whereas upregulation of KLF4 does the opposite. Mutant KRAS and cellular injuries induce KLF4 expression, and ectopic expression of KLF4 in acinar cells reduces acinar lineage- and induces ductal lineage-related marker expression. These results demonstrate that KLF4 induces ductal identity in PanIN initiation and may be a potential target for prevention of PDA initiation." @default.
- W2297256877 created "2016-06-24" @default.
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- W2297256877 date "2016-03-01" @default.
- W2297256877 modified "2023-10-17" @default.
- W2297256877 title "KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis" @default.
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- W2297256877 cites W1826126811 @default.
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- W2297256877 cites W1982781304 @default.
- W2297256877 cites W1987220381 @default.
- W2297256877 cites W1993913862 @default.
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- W2297256877 cites W2002248601 @default.
- W2297256877 cites W2002689737 @default.
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- W2297256877 cites W2010916968 @default.
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- W2297256877 cites W2026520361 @default.
- W2297256877 cites W2027768860 @default.
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- W2297256877 cites W2033589713 @default.
- W2297256877 cites W2038479484 @default.
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- W2297256877 cites W2069676892 @default.
- W2297256877 cites W2070364767 @default.
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- W2297256877 doi "https://doi.org/10.1016/j.ccell.2016.02.005" @default.
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