Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297282893> ?p ?o ?g. }
- W2297282893 endingPage "1171" @default.
- W2297282893 startingPage "1159" @default.
- W2297282893 abstract "Cardiac ischemia–reperfusion (IR) injury compromises mitochondrial oxidative phosphorylation (OxPhos) and compartmentalized intracellular energy transfer via the phosphocreatine/creatine kinase (CK) network. The restriction of ATP/ADP diffusion at the level of the mitochondrial outer membrane (MOM) is an essential element of compartmentalized energy transfer. In adult cardiomyocytes, the MOM permeability to ADP is regulated by the interaction of voltage-dependent anion channel with cytoskeletal proteins, particularly with β tubulin II. The IR-injury alters the expression and the intracellular arrangement of cytoskeletal proteins. The objective of the present study was to investigate the impact of IR on the intracellular arrangement of β tubulin II and its effect on the regulation of mitochondrial respiration. Perfused rat hearts were subjected to total ischemia (for 20 min (I20) and 45 min (I45)) or to ischemia followed by 30 min of reperfusion (I20R and I45R groups). High resolution respirometry and fluorescent confocal microscopy were used to study respiration, β tubulin II and mitochondrial arrangements in cardiac fibers. The results of these experiments evidence a heterogeneous response of mitochondria to IR-induced damage. Moreover, the intracellular rearrangement of β tubulin II, which in the control group colocalized with mitochondria, was associated with increased apparent affinity of OxPhos for ADP, decreased regulation of respiration by creatine without altering mitochondrial CK activity and the ratio between octameric to dimeric isoenzymes. The results of this study allow us to highlight changes of mitochondrial interactions with cytoskeleton as one of the possible mechanisms underlying cardiac IR injury." @default.
- W2297282893 created "2016-06-24" @default.
- W2297282893 creator A5002384137 @default.
- W2297282893 creator A5003194862 @default.
- W2297282893 creator A5005339099 @default.
- W2297282893 creator A5008680573 @default.
- W2297282893 creator A5008863721 @default.
- W2297282893 creator A5008983132 @default.
- W2297282893 creator A5034394564 @default.
- W2297282893 creator A5043404598 @default.
- W2297282893 creator A5055777045 @default.
- W2297282893 creator A5062748939 @default.
- W2297282893 creator A5085243858 @default.
- W2297282893 date "2016-06-01" @default.
- W2297282893 modified "2023-10-18" @default.
- W2297282893 title "The impact of cardiac ischemia/reperfusion on the mitochondria–cytoskeleton interactions" @default.
- W2297282893 cites W112706938 @default.
- W2297282893 cites W1515343609 @default.
- W2297282893 cites W1529250324 @default.
- W2297282893 cites W1546318372 @default.
- W2297282893 cites W1558951982 @default.
- W2297282893 cites W1583094119 @default.
- W2297282893 cites W1849159432 @default.
- W2297282893 cites W1965700291 @default.
- W2297282893 cites W1973055037 @default.
- W2297282893 cites W1974277914 @default.
- W2297282893 cites W1974590821 @default.
- W2297282893 cites W1978151809 @default.
- W2297282893 cites W1982221711 @default.
- W2297282893 cites W1987019905 @default.
- W2297282893 cites W1987698712 @default.
- W2297282893 cites W1991931009 @default.
- W2297282893 cites W1992779377 @default.
- W2297282893 cites W1995336211 @default.
- W2297282893 cites W1997587953 @default.
- W2297282893 cites W1998445234 @default.
- W2297282893 cites W2002945627 @default.
- W2297282893 cites W2004171808 @default.
- W2297282893 cites W2007545368 @default.
- W2297282893 cites W2011988428 @default.
- W2297282893 cites W2015492989 @default.
- W2297282893 cites W2015673259 @default.
- W2297282893 cites W2015859860 @default.
- W2297282893 cites W2017233874 @default.
- W2297282893 cites W2020389544 @default.
- W2297282893 cites W2021129026 @default.
- W2297282893 cites W2023362488 @default.
- W2297282893 cites W2032119894 @default.
- W2297282893 cites W2033678519 @default.
- W2297282893 cites W2037141617 @default.
- W2297282893 cites W2041686985 @default.
- W2297282893 cites W2042258372 @default.
- W2297282893 cites W2043865762 @default.
- W2297282893 cites W2051476652 @default.
- W2297282893 cites W2053691011 @default.
- W2297282893 cites W2056775926 @default.
- W2297282893 cites W2063767304 @default.
- W2297282893 cites W2068413742 @default.
- W2297282893 cites W2072528174 @default.
- W2297282893 cites W2074017960 @default.
- W2297282893 cites W2075835329 @default.
- W2297282893 cites W2076802214 @default.
- W2297282893 cites W2077930835 @default.
- W2297282893 cites W2078394646 @default.
- W2297282893 cites W2083639823 @default.
- W2297282893 cites W2092440857 @default.
- W2297282893 cites W2094283452 @default.
- W2297282893 cites W2097133939 @default.
- W2297282893 cites W2101770107 @default.
- W2297282893 cites W2106204941 @default.
- W2297282893 cites W2107034010 @default.
- W2297282893 cites W2117674493 @default.
- W2297282893 cites W2119793773 @default.
- W2297282893 cites W2125260293 @default.
- W2297282893 cites W2134017403 @default.
- W2297282893 cites W2136438732 @default.
- W2297282893 cites W2140233303 @default.
- W2297282893 cites W2147789997 @default.
- W2297282893 cites W2148486111 @default.
- W2297282893 cites W2150171020 @default.
- W2297282893 cites W2150994390 @default.
- W2297282893 cites W2155813756 @default.
- W2297282893 cites W2155969348 @default.
- W2297282893 cites W2281889878 @default.
- W2297282893 cites W2316187658 @default.
- W2297282893 cites W2401100369 @default.
- W2297282893 cites W2464867586 @default.
- W2297282893 cites W4244814842 @default.
- W2297282893 cites W4252205273 @default.
- W2297282893 doi "https://doi.org/10.1016/j.bbadis.2016.03.009" @default.
- W2297282893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26976332" @default.
- W2297282893 hasPublicationYear "2016" @default.
- W2297282893 type Work @default.
- W2297282893 sameAs 2297282893 @default.
- W2297282893 citedByCount "18" @default.
- W2297282893 countsByYear W22972828932016 @default.
- W2297282893 countsByYear W22972828932018 @default.
- W2297282893 countsByYear W22972828932019 @default.