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- W2297371006 abstract "Significance The soluble (pro)renin receptor (sPRR) is produced by protease-mediated cleavage of PRR and is elevated under certain pathological conditions. To our knowledge, no prior studies have reported the biological function of sPRR in general or the antidiuretic function of the soluble protein in particular. Here we describe a previously unreported role of sPRR in the enhancement of renal aquaporin 2 (AQP2) expression and urine-concentrating capability. We further show that sPRR acts via frizzled class receptor 8-depdendent β-catenin signaling to increase AQP2 expression in the collecting duct cells. These findings offer an unreported insight into the physiological role of sPRR in regulating fluid homeostasis. In addition, we found that liver X receptor activation by TO901317 resulted in diabetes insipidus because of the inhibition of renal PRR expression." @default.
- W2297371006 created "2016-06-24" @default.
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- W2297371006 date "2016-03-16" @default.
- W2297371006 modified "2023-10-18" @default.
- W2297371006 title "Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor" @default.
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- W2297371006 doi "https://doi.org/10.1073/pnas.1602397113" @default.
- W2297371006 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4822598" @default.
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