Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297448029> ?p ?o ?g. }
- W2297448029 endingPage "2105" @default.
- W2297448029 startingPage "2098" @default.
- W2297448029 abstract "Oleuropein is one of the primary phenolic compounds present in olive leaf. In this study, the anti-inflammatory effect of oleuropein was investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 and a zebrafish model. The inhibitory effect of oleuropein on LPS-induced NO production in macrophages was supported by the suppression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). In addition, our enzyme immunoassay showed that oleuropein suppressed the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-6 (IL-6). Oleuropein inhibited the translocation of p65 by suppressing phosphorylation of inhibitory kappa B-α (IκB-α). Oleuropein also decreased activation of ERK1/2 and JNK, which are associated with LPS-induced inflammation, and its downstream gene of AP-1. Furthermore, oleuropein inhibited LPS-stimulated NO generation in a zebrafish model. Taken together, our results demonstrated that oleuropein could reduce inflammatory responses by inhibiting TLR and MAPK signaling, and may be used as an anti-inflammatory agent." @default.
- W2297448029 created "2016-06-24" @default.
- W2297448029 creator A5001869095 @default.
- W2297448029 creator A5019145849 @default.
- W2297448029 creator A5020244549 @default.
- W2297448029 creator A5070355828 @default.
- W2297448029 creator A5074753423 @default.
- W2297448029 creator A5089452267 @default.
- W2297448029 date "2015-02-12" @default.
- W2297448029 modified "2023-10-17" @default.
- W2297448029 title "Oleuropein Suppresses LPS-Induced Inflammatory Responses in RAW 264.7 Cell and Zebrafish" @default.
- W2297448029 cites W1540508935 @default.
- W2297448029 cites W1549679997 @default.
- W2297448029 cites W1965037168 @default.
- W2297448029 cites W1966901116 @default.
- W2297448029 cites W1979230311 @default.
- W2297448029 cites W1995744610 @default.
- W2297448029 cites W1998363691 @default.
- W2297448029 cites W1999457976 @default.
- W2297448029 cites W2002427738 @default.
- W2297448029 cites W2002801265 @default.
- W2297448029 cites W2009386000 @default.
- W2297448029 cites W2011928284 @default.
- W2297448029 cites W2013285507 @default.
- W2297448029 cites W2014224712 @default.
- W2297448029 cites W2018822118 @default.
- W2297448029 cites W2019370793 @default.
- W2297448029 cites W2021046584 @default.
- W2297448029 cites W2023670376 @default.
- W2297448029 cites W2025761802 @default.
- W2297448029 cites W2032549132 @default.
- W2297448029 cites W2034371559 @default.
- W2297448029 cites W2036747221 @default.
- W2297448029 cites W2038970880 @default.
- W2297448029 cites W2057257335 @default.
- W2297448029 cites W2064119981 @default.
- W2297448029 cites W2064711537 @default.
- W2297448029 cites W2065017189 @default.
- W2297448029 cites W2083543804 @default.
- W2297448029 cites W2101772709 @default.
- W2297448029 cites W2119088209 @default.
- W2297448029 cites W2120266360 @default.
- W2297448029 cites W2138992293 @default.
- W2297448029 cites W2155702314 @default.
- W2297448029 cites W4238497443 @default.
- W2297448029 doi "https://doi.org/10.1021/jf505894b" @default.
- W2297448029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25613688" @default.
- W2297448029 hasPublicationYear "2015" @default.
- W2297448029 type Work @default.
- W2297448029 sameAs 2297448029 @default.
- W2297448029 citedByCount "86" @default.
- W2297448029 countsByYear W22974480292015 @default.
- W2297448029 countsByYear W22974480292016 @default.
- W2297448029 countsByYear W22974480292017 @default.
- W2297448029 countsByYear W22974480292018 @default.
- W2297448029 countsByYear W22974480292019 @default.
- W2297448029 countsByYear W22974480292020 @default.
- W2297448029 countsByYear W22974480292021 @default.
- W2297448029 countsByYear W22974480292022 @default.
- W2297448029 countsByYear W22974480292023 @default.
- W2297448029 crossrefType "journal-article" @default.
- W2297448029 hasAuthorship W2297448029A5001869095 @default.
- W2297448029 hasAuthorship W2297448029A5019145849 @default.
- W2297448029 hasAuthorship W2297448029A5020244549 @default.
- W2297448029 hasAuthorship W2297448029A5070355828 @default.
- W2297448029 hasAuthorship W2297448029A5074753423 @default.
- W2297448029 hasAuthorship W2297448029A5089452267 @default.
- W2297448029 hasConcept C104317684 @default.
- W2297448029 hasConcept C178790620 @default.
- W2297448029 hasConcept C181199279 @default.
- W2297448029 hasConcept C185592680 @default.
- W2297448029 hasConcept C203014093 @default.
- W2297448029 hasConcept C2776878037 @default.
- W2297448029 hasConcept C2776914184 @default.
- W2297448029 hasConcept C2777622882 @default.
- W2297448029 hasConcept C2777957096 @default.
- W2297448029 hasConcept C2778004101 @default.
- W2297448029 hasConcept C2778754761 @default.
- W2297448029 hasConcept C519581460 @default.
- W2297448029 hasConcept C55493867 @default.
- W2297448029 hasConcept C86803240 @default.
- W2297448029 hasConcept C98274493 @default.
- W2297448029 hasConceptScore W2297448029C104317684 @default.
- W2297448029 hasConceptScore W2297448029C178790620 @default.
- W2297448029 hasConceptScore W2297448029C181199279 @default.
- W2297448029 hasConceptScore W2297448029C185592680 @default.
- W2297448029 hasConceptScore W2297448029C203014093 @default.
- W2297448029 hasConceptScore W2297448029C2776878037 @default.
- W2297448029 hasConceptScore W2297448029C2776914184 @default.
- W2297448029 hasConceptScore W2297448029C2777622882 @default.
- W2297448029 hasConceptScore W2297448029C2777957096 @default.
- W2297448029 hasConceptScore W2297448029C2778004101 @default.
- W2297448029 hasConceptScore W2297448029C2778754761 @default.
- W2297448029 hasConceptScore W2297448029C519581460 @default.
- W2297448029 hasConceptScore W2297448029C55493867 @default.
- W2297448029 hasConceptScore W2297448029C86803240 @default.
- W2297448029 hasConceptScore W2297448029C98274493 @default.
- W2297448029 hasIssue "7" @default.