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- W2297477651 abstract "Background: Asthma is increasingly recognized as a mediator-driven inflammatory process in the lungs. Leukotrienes (LTs) and prostaglandins (PGs), which are two families of proinflammatory mediators generated via the arachidonic acid metabolism, have been shown to play an important role in the inflammatory cascade of the airways. The aim of this study was to examine whether plasma leukotriene E4 (LTE4) and 9α, 11 β-PGF2 were biomarkers of asthma exacerbations in 2- to 5- year-old children. Methods: Sixty 2- to 5-year-old children who were hospitalized for acute asthma were assigned to receive budesonide (Pulmicort) (n=32) or oral prednisolone (n=28). The budesonide group received nebulized fenoterol (Berotec) together with the nebulized budesonide, and the prednisolone group received nebulized fenoterol and oral prednisolone. Pulmonary index scores (PIS), including respiratory rate, wheezing, inspiratory/expiratory ratios, and the use of accessory muscles during respiration, were measured as indices of clinical progression. Blood samples were collected at admission and discharge and plasma concentrations of 9α, 11 β-PGF2 and LTE4 were determined. Results: Fifty-two children completed the study; both budesonide (n=28) and prednisolone (n=24) treatment significantly improved acute asthma symptoms and PIS; however, there was no significant difference in plasma levels of LTE4 and PGF2 between asthma exacerbation and convalescence in both groups. Conclusion: Plasma levels of LTE4 and 9α, 11β-PGF2 were not good indicators of exacerbation in asthmatic children." @default.
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- W2297477651 date "2008-12-01" @default.
- W2297477651 modified "2023-09-24" @default.
- W2297477651 title "Plasma Levels of Leukotriene E4 and 9α, 11 β-PGF2 in Asthmatic Young Children during Exacerbation and Convalescence" @default.
- W2297477651 doi "https://doi.org/10.6136/jms.2008.28(6).233" @default.
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