Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297535260> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2297535260 endingPage "12" @default.
- W2297535260 startingPage "505" @default.
- W2297535260 abstract "Hydrolysis of D-valyl-L-leucyl-L-arginine p-nitroanilide (D-Val-Leu-Arg-Nan) at five different concentrations (10-20 microM) by human urinary kallikrein was studied in the absence and in the presence of increasing concentrations of basic pancreatic trypsin inhibitor (BPTI) (1.35-9.15 nM). The data indicate that the inhibition of human urinary kallikrein by BPTI is not a simple competitive inhibition as reported by others, but that it is a competitive inhibition of the parabolic type, with two inhibitor molecules binding to one enzyme molecule, with the formation of a ternary enzymatic complex. Statistical analysis of the experimental data supports the kinetic model proposed. The calculated values of the constants Ki and Kii were 16.20 nM and 1.10 nM, respectively. It is noteworthy that the Kii < Ki, i.e., the second BPTI molecule binds to the enzyme with a larger affinity suggesting that this second binding site was probably created or positively modulated as a consequence of the binding of the first BPTI molecule." @default.
- W2297535260 created "2016-06-24" @default.
- W2297535260 creator A5001885290 @default.
- W2297535260 creator A5005875428 @default.
- W2297535260 creator A5016251804 @default.
- W2297535260 creator A5027016797 @default.
- W2297535260 creator A5040510636 @default.
- W2297535260 creator A5042529746 @default.
- W2297535260 creator A5053459717 @default.
- W2297535260 date "1995-05-01" @default.
- W2297535260 modified "2023-09-27" @default.
- W2297535260 title "Kinetic mechanism of the inhibition of human urinary kallikrein by basic pancreatic trypsin inhibitor." @default.
- W2297535260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8555969" @default.
- W2297535260 hasPublicationYear "1995" @default.
- W2297535260 type Work @default.
- W2297535260 sameAs 2297535260 @default.
- W2297535260 citedByCount "1" @default.
- W2297535260 crossrefType "journal-article" @default.
- W2297535260 hasAuthorship W2297535260A5001885290 @default.
- W2297535260 hasAuthorship W2297535260A5005875428 @default.
- W2297535260 hasAuthorship W2297535260A5016251804 @default.
- W2297535260 hasAuthorship W2297535260A5027016797 @default.
- W2297535260 hasAuthorship W2297535260A5040510636 @default.
- W2297535260 hasAuthorship W2297535260A5042529746 @default.
- W2297535260 hasAuthorship W2297535260A5053459717 @default.
- W2297535260 hasConcept C107824862 @default.
- W2297535260 hasConcept C121332964 @default.
- W2297535260 hasConcept C148898269 @default.
- W2297535260 hasConcept C150757390 @default.
- W2297535260 hasConcept C178790620 @default.
- W2297535260 hasConcept C181199279 @default.
- W2297535260 hasConcept C185592680 @default.
- W2297535260 hasConcept C2780340462 @default.
- W2297535260 hasConcept C32909587 @default.
- W2297535260 hasConcept C41183919 @default.
- W2297535260 hasConcept C52853521 @default.
- W2297535260 hasConcept C55493867 @default.
- W2297535260 hasConcept C56856141 @default.
- W2297535260 hasConcept C62520636 @default.
- W2297535260 hasConcept C71240020 @default.
- W2297535260 hasConcept C86756495 @default.
- W2297535260 hasConcept C94412978 @default.
- W2297535260 hasConceptScore W2297535260C107824862 @default.
- W2297535260 hasConceptScore W2297535260C121332964 @default.
- W2297535260 hasConceptScore W2297535260C148898269 @default.
- W2297535260 hasConceptScore W2297535260C150757390 @default.
- W2297535260 hasConceptScore W2297535260C178790620 @default.
- W2297535260 hasConceptScore W2297535260C181199279 @default.
- W2297535260 hasConceptScore W2297535260C185592680 @default.
- W2297535260 hasConceptScore W2297535260C2780340462 @default.
- W2297535260 hasConceptScore W2297535260C32909587 @default.
- W2297535260 hasConceptScore W2297535260C41183919 @default.
- W2297535260 hasConceptScore W2297535260C52853521 @default.
- W2297535260 hasConceptScore W2297535260C55493867 @default.
- W2297535260 hasConceptScore W2297535260C56856141 @default.
- W2297535260 hasConceptScore W2297535260C62520636 @default.
- W2297535260 hasConceptScore W2297535260C71240020 @default.
- W2297535260 hasConceptScore W2297535260C86756495 @default.
- W2297535260 hasConceptScore W2297535260C94412978 @default.
- W2297535260 hasIssue "5" @default.
- W2297535260 hasLocation W22975352601 @default.
- W2297535260 hasOpenAccess W2297535260 @default.
- W2297535260 hasPrimaryLocation W22975352601 @default.
- W2297535260 hasRelatedWork W1495018910 @default.
- W2297535260 hasRelatedWork W2000207142 @default.
- W2297535260 hasRelatedWork W2002670489 @default.
- W2297535260 hasRelatedWork W2297535260 @default.
- W2297535260 hasRelatedWork W2305950248 @default.
- W2297535260 hasRelatedWork W2398687087 @default.
- W2297535260 hasRelatedWork W2409628809 @default.
- W2297535260 hasRelatedWork W2409885431 @default.
- W2297535260 hasRelatedWork W2418977795 @default.
- W2297535260 hasRelatedWork W2432838425 @default.
- W2297535260 hasVolume "28" @default.
- W2297535260 isParatext "false" @default.
- W2297535260 isRetracted "false" @default.
- W2297535260 magId "2297535260" @default.
- W2297535260 workType "article" @default.