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• W2297616401 abstract "The doping of biocompatible nanomaterials into ultrahigh molecular weight polyethylene (UHMWPE) to improve the biocompatibility and reduce the wear debris is of great significance to prolonging implantation time of UHMWPE as the bearing material for artificial joints. This study shows that UHMWPE can form a composite with nanocrystalline cellulose (NCC, a hydrophilic nanosized material with a high aspect ratio) by ball-milling and hot-pressing. Compared to pure UHMWPE, the NCC/UHMWPE composite exhibits improved tribological characteristics with reduced generation of wear debris. The underlying mechanism is related to the weak binding between hydrophilic NCC and hydrophobic UHMWPE. The hydrophilic, rigid NCC particles tend to detach from the UHMWPE surface during friction, which could move with the rubbing surface, serve as a thin lubricant layer, and protect the UHMWPE substrate from abrasion. The biological safety of the NCC/UHMWPE composite, as tested by MC3T3-E1 preosteoblast cells and macrophage RAW264.7 cells, is high, with significantly lower inflammatory responses/cytotoxicity than pure UHMWPE. The NCC/UHMWPE composite therefore could be a promising alternative to the current UHMWPE for bearing applications." @default.
• W2297616401 created "2016-06-24" @default.
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• W2297616401 date "2015-12-22" @default.
• W2297616401 modified "2023-10-15" @default.
• W2297616401 title "Nanocrystalline Cellulose Improves the Biocompatibility and Reduces the Wear Debris of Ultrahigh Molecular Weight Polyethylene <i>via</i> Weak Binding" @default.
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• W2297616401 doi "https://doi.org/10.1021/acsnano.5b04393" @default.
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• W2297616401 hasPublicationYear "2015" @default.
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