Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297643172> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2297643172 endingPage "88" @default.
- W2297643172 startingPage "379" @default.
- W2297643172 abstract "Lymphocytes become activated when antigen receptors on the cell surface are cross-linked, or when they are exposed to agents that mimic this signal. Although such activation is usually associated with the production of immune mediators (e.g. antibodies, cytokines) and entry into the cell cycle, it can alternatively lead to death via apoptosis. This activation-induced apoptosis was first observed in developing lymphocytes and has been proposed as a mechanism for negative selection, by which immature cells with potential for autoreactivity are eliminated from the maturation pathway. Activation-induced apoptosis has also been observed in normal, mature lymphocytes under some conditions, and this may account for the phenomena of peripheral deletion, in which mature T cells are eliminated upon exposure to high doses of antigen. It may also be an important mechanism whereby CD4+ T cells are depleted in HIV+ individuals. Although the phenomenon of activation-induced apoptosis is not understood, recent studies have begun to implicate specific signal transduction pathways and gene products in the process. Among the latter is the c-myc proto-oncogene, which paradoxically can play an essential role in several forms of apoptosis, including that induced by activation of lymphocytes." @default.
- W2297643172 created "2016-06-24" @default.
- W2297643172 creator A5014109124 @default.
- W2297643172 creator A5062682623 @default.
- W2297643172 creator A5064622016 @default.
- W2297643172 creator A5075655484 @default.
- W2297643172 date "1992-12-01" @default.
- W2297643172 modified "2023-10-18" @default.
- W2297643172 title "Activation-induced apoptosis in lymphoid systems." @default.
- W2297643172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1286165" @default.
- W2297643172 hasPublicationYear "1992" @default.
- W2297643172 type Work @default.
- W2297643172 sameAs 2297643172 @default.
- W2297643172 citedByCount "20" @default.
- W2297643172 countsByYear W22976431722012 @default.
- W2297643172 countsByYear W22976431722013 @default.
- W2297643172 countsByYear W22976431722014 @default.
- W2297643172 countsByYear W22976431722018 @default.
- W2297643172 crossrefType "journal-article" @default.
- W2297643172 hasAuthorship W2297643172A5014109124 @default.
- W2297643172 hasAuthorship W2297643172A5062682623 @default.
- W2297643172 hasAuthorship W2297643172A5064622016 @default.
- W2297643172 hasAuthorship W2297643172A5075655484 @default.
- W2297643172 hasConcept C147483822 @default.
- W2297643172 hasConcept C170493617 @default.
- W2297643172 hasConcept C190283241 @default.
- W2297643172 hasConcept C19317047 @default.
- W2297643172 hasConcept C203014093 @default.
- W2297643172 hasConcept C2776090121 @default.
- W2297643172 hasConcept C31573885 @default.
- W2297643172 hasConcept C54355233 @default.
- W2297643172 hasConcept C62478195 @default.
- W2297643172 hasConcept C86803240 @default.
- W2297643172 hasConcept C8891405 @default.
- W2297643172 hasConcept C95444343 @default.
- W2297643172 hasConceptScore W2297643172C147483822 @default.
- W2297643172 hasConceptScore W2297643172C170493617 @default.
- W2297643172 hasConceptScore W2297643172C190283241 @default.
- W2297643172 hasConceptScore W2297643172C19317047 @default.
- W2297643172 hasConceptScore W2297643172C203014093 @default.
- W2297643172 hasConceptScore W2297643172C2776090121 @default.
- W2297643172 hasConceptScore W2297643172C31573885 @default.
- W2297643172 hasConceptScore W2297643172C54355233 @default.
- W2297643172 hasConceptScore W2297643172C62478195 @default.
- W2297643172 hasConceptScore W2297643172C86803240 @default.
- W2297643172 hasConceptScore W2297643172C8891405 @default.
- W2297643172 hasConceptScore W2297643172C95444343 @default.
- W2297643172 hasIssue "6" @default.
- W2297643172 hasLocation W22976431721 @default.
- W2297643172 hasOpenAccess W2297643172 @default.
- W2297643172 hasPrimaryLocation W22976431721 @default.
- W2297643172 hasRelatedWork W1565632507 @default.
- W2297643172 hasRelatedWork W1979505789 @default.
- W2297643172 hasRelatedWork W1987695408 @default.
- W2297643172 hasRelatedWork W2003720298 @default.
- W2297643172 hasRelatedWork W2074148448 @default.
- W2297643172 hasRelatedWork W2151098840 @default.
- W2297643172 hasRelatedWork W2327002369 @default.
- W2297643172 hasRelatedWork W2329088167 @default.
- W2297643172 hasRelatedWork W2594560619 @default.
- W2297643172 hasRelatedWork W3160804663 @default.
- W2297643172 hasVolume "4" @default.
- W2297643172 isParatext "false" @default.
- W2297643172 isRetracted "false" @default.
- W2297643172 magId "2297643172" @default.
- W2297643172 workType "article" @default.