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- W2297667718 abstract "The endogenous opioid system is involved in alcohol-induced reward and development of alcohol use disorder (AUD). Alcohol exposure induces a number of changes in the endogenous opioid system, both after acute and chronic intake. Opioid agonists and antagonists can modulate alcohol consumption and opioid antagonists are therefore used in pharmacotherapy of AUD. There are three different receptor types—mu-, delta- and kappa-opioid receptors—with different affinity for the three opioid peptides: beta-endorphin, enkephalin, and dynorphin. The three systems also mediate different effects. Positive effects are generally attributed to the endorphins and enkephalins, while negative effects are mediated by dynorphins. Dysfunction in any or all of these systems contribute to development of AUD. Genetic and environmental factors interact to cause long-term changes in endogenous opioid function, which can affect vulnerability to AUD and efficacy of treatment with opioid antagonists." @default.
- W2297667718 created "2016-06-24" @default.
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- W2297667718 date "2016-01-01" @default.
- W2297667718 modified "2023-10-02" @default.
- W2297667718 title "Alcohol and Endogenous Opioids" @default.
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- W2297667718 doi "https://doi.org/10.1016/b978-0-12-800213-1.00037-7" @default.
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