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- W2297672205 abstract "Discriminative-stimulus (Sd) properties of cannabinergic (CB) ligands other than the CB-1 partial agonist Δ9–THC have not been studied in nonhuman primates. The present studies were conducted to systematically examine the Sd effects of the novel CB-1 full agonist AM 4054 in squirrel monkeys (n=4) trained under a two-lever procedure to discriminate i.m. injections of saline from 0.01 mg/kg AM 4054. Results show that the AM 4054 Sd was acquired with varying speed among monkeys. Following acquisition, ≤ 5% and ≥ 97% drug-lever responding occurred following injection with, respectively, saline and AM 4054. Under test conditions, AM 4054 produced dose-related (0.001–0.01 mg/kg) increases in drug-lever responding, with little or no effect on response rate and >90% substitution following 0.0056 mg/kg AM 4054. The Sd effects of 0.01 mg/kg AM 4054 were fully evident 1 hr after injection and dissipated gradually over 12 hr. Dose-related substitution for AM 4054 also occurred with the CB-1 agonists Δ9–THC (0.03–3 mg/kg) and methanandamide (0.3–10 mg/kg). In antagonism experiments, SR 141716A dose-dependently reduced the Sd effects of 0.01 mg/kg AM 4054, with full attenuation after 1.0 mg/kg of the CB-1 antagonist. Together, these data demonstrate that the discriminative stimulus effects of AM 4054 are CB-1-mediated and overlap those of the CB1 agonists Δ9–THC and AM 356 (supported by NIH/NIDA DA19205 and DA7252)." @default.
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- W2297672205 date "2008-03-01" @default.
- W2297672205 modified "2023-10-16" @default.
- W2297672205 title "Discriminative‐stimulus effects of the novel CB1 agonist AM 4054 in squirel monkeys" @default.
- W2297672205 doi "https://doi.org/10.1096/fasebj.22.1_supplement.711.8" @default.
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