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• W2297677027 abstract "Purpose: To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an elderly population. Methods: We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires. Results: Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 ± 3.6 years. Mean MPOD at 0.5° eccentricity was 0.57 ± 0.25 density units (DU) and was higher in women than in men (0.59 ± 0.25 vs. 0.53 ± 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 ± 0.25 vs. 0.61 ± 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 μg/L and 20.0 μg/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (β = 0.11, P = 0.021). Conclusions: This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an elderly population." @default.
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• W2297677027 date "2016-03-14" @default.
• W2297677027 modified "2023-10-11" @default.
• W2297677027 title "Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study" @default.
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• W2297677027 doi "https://doi.org/10.1167/iovs.15-18007" @default.
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