Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297701075> ?p ?o ?g. }
- W2297701075 abstract "Mannose-binding lectin (MBL) is a member of the collectin protein family that acts as a defence molecule and plays an important role in innate immune responses. MBL binds to carbohydrates on the surface of microorganisms, leading to opsonisation and phagocytosis. This binding also results in activation of the complement system. It was already described that MBL recognizes and binds to gp120 protein of human immunodeficiency virus-1 (HIV-1), but the role of such molecule on HIV infection is still debated. Several MBL2 gene polymorphisms were described as capable of disrupting the MBL protein resulting in low serum levels and increased susceptibility to infections. Among them, two variants in the promoter region (-550 H/L and -221 X/Y) and three variants in exon 1, Arg52Cys, Gly54Asp and Gly57Glu (that are collectively called allele 0, while the combination of the three wild-type alleles is called A), were analyzed in the present work. Our aim was to investigate the role of MBL on HIV-1 infected subjects through the analysis of the polymorphisms located in the MBL2 promoter and exon 1 regions. We investigated the prevalence of the variant alleles in 410 HIV-1 infected patients from the Hospital de Clinicas de Porto Alegre (HCPA), and in 345 uninfected individuals. All individuals are from Southern Brazil. The variants from the promoter were genotyped using PCRSSP and the variants from the exon 1 were analyzed by Real-time PCR using a melting temperature assay and were confirmed by PCR-RFLP. Polymorphisms genotype and allele frequencies in the two groups analyzed, namely HIV-1 positive subjects and controls, were compared using Chi-square-test. The analyses were performed subdividing the individuals according to their ethnic" @default.
- W2297701075 created "2016-06-24" @default.
- W2297701075 creator A5055207864 @default.
- W2297701075 date "2010-01-01" @default.
- W2297701075 modified "2023-09-24" @default.
- W2297701075 title "O PAPEL DOS POLIMORFISMOS DO GENE DA PROTEÍNA DE LIGAÇÃO À MANOSE EM PACIENTES INFECTADOS PELO VÍRUS DA IMUNODEFICIÊNCIA HUMANA" @default.
- W2297701075 cites W112516434 @default.
- W2297701075 cites W1606330082 @default.
- W2297701075 cites W1767363304 @default.
- W2297701075 cites W1843703103 @default.
- W2297701075 cites W1911746360 @default.
- W2297701075 cites W1964363433 @default.
- W2297701075 cites W1964728695 @default.
- W2297701075 cites W1966979307 @default.
- W2297701075 cites W1966992941 @default.
- W2297701075 cites W1970344276 @default.
- W2297701075 cites W1975302980 @default.
- W2297701075 cites W1977926290 @default.
- W2297701075 cites W1982024820 @default.
- W2297701075 cites W1986638010 @default.
- W2297701075 cites W1986908601 @default.
- W2297701075 cites W1988365133 @default.
- W2297701075 cites W1991201590 @default.
- W2297701075 cites W1991502041 @default.
- W2297701075 cites W1997731702 @default.
- W2297701075 cites W2000426221 @default.
- W2297701075 cites W2000671553 @default.
- W2297701075 cites W2003701673 @default.
- W2297701075 cites W2005044802 @default.
- W2297701075 cites W2006771360 @default.
- W2297701075 cites W2008904347 @default.
- W2297701075 cites W2012139740 @default.
- W2297701075 cites W2014813076 @default.
- W2297701075 cites W2015040325 @default.
- W2297701075 cites W2017325020 @default.
- W2297701075 cites W2020340107 @default.
- W2297701075 cites W2024083825 @default.
- W2297701075 cites W2024702568 @default.
- W2297701075 cites W2028342113 @default.
- W2297701075 cites W2030027782 @default.
- W2297701075 cites W2030420678 @default.
- W2297701075 cites W2030678127 @default.
- W2297701075 cites W2033916375 @default.
- W2297701075 cites W2034223728 @default.
- W2297701075 cites W2034573106 @default.
- W2297701075 cites W2035158298 @default.
- W2297701075 cites W2037003935 @default.
- W2297701075 cites W2038771810 @default.
- W2297701075 cites W2039259074 @default.
- W2297701075 cites W2040860660 @default.
- W2297701075 cites W2041274212 @default.
- W2297701075 cites W2042815830 @default.
- W2297701075 cites W2045138633 @default.
- W2297701075 cites W2047233465 @default.
- W2297701075 cites W2048344900 @default.
- W2297701075 cites W2049980057 @default.
- W2297701075 cites W2051718508 @default.
- W2297701075 cites W2053264416 @default.
- W2297701075 cites W2055438459 @default.
- W2297701075 cites W2056548382 @default.
- W2297701075 cites W2057527788 @default.
- W2297701075 cites W2058963746 @default.
- W2297701075 cites W2059332413 @default.
- W2297701075 cites W2060260578 @default.
- W2297701075 cites W2064053782 @default.
- W2297701075 cites W2064927709 @default.
- W2297701075 cites W2070676224 @default.
- W2297701075 cites W2070902941 @default.
- W2297701075 cites W2072095725 @default.
- W2297701075 cites W2073503811 @default.
- W2297701075 cites W2074087022 @default.
- W2297701075 cites W2074952580 @default.
- W2297701075 cites W2086535889 @default.
- W2297701075 cites W2086660485 @default.
- W2297701075 cites W2087631385 @default.
- W2297701075 cites W2088974691 @default.
- W2297701075 cites W2089057554 @default.
- W2297701075 cites W2089889585 @default.
- W2297701075 cites W2091035072 @default.
- W2297701075 cites W2091340735 @default.
- W2297701075 cites W2094016451 @default.
- W2297701075 cites W2095285976 @default.
- W2297701075 cites W2095701822 @default.
- W2297701075 cites W2096428863 @default.
- W2297701075 cites W2099288908 @default.
- W2297701075 cites W2100967062 @default.
- W2297701075 cites W2102977207 @default.
- W2297701075 cites W2105614022 @default.
- W2297701075 cites W2111806738 @default.
- W2297701075 cites W2114809388 @default.
- W2297701075 cites W2115816960 @default.
- W2297701075 cites W2118352384 @default.
- W2297701075 cites W2120112329 @default.
- W2297701075 cites W2120418867 @default.
- W2297701075 cites W2120571619 @default.
- W2297701075 cites W2123584222 @default.
- W2297701075 cites W2129571554 @default.
- W2297701075 cites W2130997583 @default.
- W2297701075 cites W2132984312 @default.
- W2297701075 cites W2133299937 @default.