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• W2297744038 abstract "// Mantang Qiu 1,2,* , Dongjie Feng 1,* , Haitian Zhang 1,3,* , Wenjia Xia 1,2 , Youtao Xu 1 , Jie Wang 1,4 , Gaochao Dong 1,4 , Yewei Zhang 5 , Rong Yin 1 and Lin Xu 1 1 Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China 2 The Fourth Clinical College of Nanjing Medical University, Nanjing, China 3 The First Clinical Medical College of Nanjing Medical University, Nanjing, China 4 Department of Scientific Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China 5 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, China * These authors have contributed equally to this work Correspondence to: Lin Xu, email: // Rong Yin, email: // Keywords : lung adenocarcinoma, lncRNA, expression profile, LCAL6 Received : September 20, 2015 Accepted : February 07, 2016 Published : February 21, 2016 Abstract Increasing evidence has highlighted the critical roles of long non-coding RNAs (lncRNAs) as biomarkers and therapeutic targets for cancer. Here, we characterized lncRNA expression profile in lung adenocarcinoma (LUAD). A training-validation method was applied to identify differentially expressed lncRNAs between LUAD samples and normal samples. 856 differentially expressed lncRNAs were identified. Bioinformatics analyses showed that these lncRNAs were located nearby transcription start sites and key regulators of cancer and these lncRNAs were involved in many critical biological processes. We found the lung cancer associated lncRNA 6 (LCAL6) was significantly unregulated and predicted survival in LUAD. Silence of LCAL6 inhibited LUAD tumor cell growth both in vitro and in vivo . To summary, we comprehensively analyze lncRNA expression profile in LUAD and provide resources for further search for clinical biomarkers and therapeutic targets of LUAD." @default.
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• W2297744038 date "2016-02-21" @default.
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• W2297744038 title "Comprehensive analysis of lncRNA expression profiles and identification of functional lncRNAs in lung adenocarcinoma" @default.
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• W2297744038 doi "https://doi.org/10.18632/oncotarget.7559" @default.
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