FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297782009> ?p ?o ?g. }

• W2297782009 endingPage "219" @default.
• W2297782009 startingPage "213" @default.
• W2297782009 abstract "The vitamin D receptor (VDR) is a ligand-activated transcription factor that regulates gene expression in many cell types, including immune cells. It requires binding of 1,25 dihydroxy vitamin D3 (1,25D3) for activation. Many autoimmune diseases show latitude-dependent prevalence and/or association with vitamin D deficiency, and vitamin D supplementation is commonly used in their clinical management. 1,25D3 is regulated by genes associated with the risk of autoimmune diseases and predominantly expressed in myeloid cells. We determined the VDR cistrome in monocytes and monocyte-derived inflammatory (DC1) and tolerogenic dendritic cells (DC2). VDR motifs were highly overrepresented in ChIP-Seq peaks in stimulated monocyte (40%), DC1 (21%) and DC2 (47%), P<E−100 for all. Of the nearly 11 000 VDR-binding peaks identified across the genome in DC1s, 1317 were shared with DC2s (91% of DC2 sites) and 1579 with monocytes (83% of monocyte sites). Latitude-dependent autoimmune disease risk polymorphisms were highly overrepresented within 5 kb of the peaks. Several transcription factor recognition motifs were highly overrepresented in the peaks, including those for the autoimmune risk gene, BATF. This evidence indicates that VDR regulates hundreds of myeloid cell genes and that the molecular pathways controlled by VDR in these cells are important in maintaining tolerance." @default.
• W2297782009 created "2016-06-24" @default.
• W2297782009 creator A5016365794 @default.
• W2297782009 creator A5018817230 @default.
• W2297782009 creator A5025305464 @default.
• W2297782009 creator A5034809536 @default.
• W2297782009 creator A5046766716 @default.
• W2297782009 creator A5049828619 @default.
• W2297782009 creator A5055391251 @default.
• W2297782009 creator A5063505884 @default.
• W2297782009 creator A5068690410 @default.
• W2297782009 creator A5087519016 @default.
• W2297782009 creator A5087598197 @default.
• W2297782009 date "2016-03-17" @default.
• W2297782009 modified "2023-09-26" @default.
• W2297782009 title "Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases" @default.
• W2297782009 cites W1417251146 @default.
• W2297782009 cites W1638979393 @default.
• W2297782009 cites W1963608958 @default.
• W2297782009 cites W1977216303 @default.
• W2297782009 cites W1981346652 @default.
• W2297782009 cites W1989590412 @default.
• W2297782009 cites W1992204488 @default.
• W2297782009 cites W1992555622 @default.
• W2297782009 cites W2000485891 @default.
• W2297782009 cites W2001721660 @default.
• W2297782009 cites W2009178411 @default.
• W2297782009 cites W2011028088 @default.
• W2297782009 cites W2014677321 @default.
• W2297782009 cites W2016474019 @default.
• W2297782009 cites W2017648846 @default.
• W2297782009 cites W2024413239 @default.
• W2297782009 cites W2027380041 @default.
• W2297782009 cites W2029081372 @default.
• W2297782009 cites W2036012609 @default.
• W2297782009 cites W2040547343 @default.
• W2297782009 cites W2075750207 @default.
• W2297782009 cites W2078169669 @default.
• W2297782009 cites W2082637121 @default.
• W2297782009 cites W2084380425 @default.
• W2297782009 cites W2088402590 @default.
• W2297782009 cites W2094205468 @default.
• W2297782009 cites W2094603538 @default.
• W2297782009 cites W2097302700 @default.
• W2297782009 cites W2098377388 @default.
• W2297782009 cites W2101087890 @default.
• W2297782009 cites W2103136723 @default.
• W2297782009 cites W2103529868 @default.
• W2297782009 cites W2103979725 @default.
• W2297782009 cites W2109978145 @default.
• W2297782009 cites W2112541034 @default.
• W2297782009 cites W2112552424 @default.
• W2297782009 cites W2112588696 @default.
• W2297782009 cites W2126510876 @default.
• W2297782009 cites W2126574528 @default.
• W2297782009 cites W2134397552 @default.
• W2297782009 cites W2135403800 @default.
• W2297782009 cites W2137789008 @default.
• W2297782009 cites W2138258120 @default.
• W2297782009 cites W2139890289 @default.
• W2297782009 cites W2140876277 @default.
• W2297782009 cites W2143625465 @default.
• W2297782009 cites W2144378498 @default.
• W2297782009 cites W2144714963 @default.
• W2297782009 cites W2145225260 @default.
• W2297782009 cites W2155615155 @default.
• W2297782009 cites W2158479500 @default.
• W2297782009 cites W2159638886 @default.
• W2297782009 cites W2162166699 @default.
• W2297782009 cites W2164877979 @default.
• W2297782009 cites W2166722740 @default.
• W2297782009 cites W2170551349 @default.
• W2297782009 doi "https://doi.org/10.1038/gene.2016.12" @default.
• W2297782009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4895389" @default.
• W2297782009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26986782" @default.
• W2297782009 hasPublicationYear "2016" @default.
• W2297782009 type Work @default.
• W2297782009 sameAs 2297782009 @default.
• W2297782009 citedByCount "49" @default.
• W2297782009 countsByYear W22977820092016 @default.
• W2297782009 countsByYear W22977820092017 @default.
• W2297782009 countsByYear W22977820092018 @default.
• W2297782009 countsByYear W22977820092019 @default.
• W2297782009 countsByYear W22977820092020 @default.
• W2297782009 countsByYear W22977820092021 @default.
• W2297782009 countsByYear W22977820092022 @default.
• W2297782009 countsByYear W22977820092023 @default.
• W2297782009 crossrefType "journal-article" @default.
• W2297782009 hasAuthorship W2297782009A5016365794 @default.
• W2297782009 hasAuthorship W2297782009A5018817230 @default.
• W2297782009 hasAuthorship W2297782009A5025305464 @default.
• W2297782009 hasAuthorship W2297782009A5034809536 @default.
• W2297782009 hasAuthorship W2297782009A5046766716 @default.
• W2297782009 hasAuthorship W2297782009A5049828619 @default.
• W2297782009 hasAuthorship W2297782009A5055391251 @default.
• W2297782009 hasAuthorship W2297782009A5063505884 @default.
• W2297782009 hasAuthorship W2297782009A5068690410 @default.
• W2297782009 hasAuthorship W2297782009A5087519016 @default.

• next