Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297805513> ?p ?o ?g. }
- W2297805513 endingPage "116" @default.
- W2297805513 startingPage "99" @default.
- W2297805513 abstract "Prostaglandin G2 (PGG2) is a labile endoperoxide produced physiologically following exposure of platelets to aggregating agents. We report here studies using isolated PGG2. This agent stimulates a concentration-dependent internal platelet contraction very similar to that produced by the calcium ionophore A23187. EDTA prevented platelet aggregation but did not prevent PGG2-stimulated internal contraction or secretion. In contrast, prostaglandin E1 and dibutyryl cyclic AMP inhich selectively labilizes platelet granules, was added to platelets together with PGG2 there was a superadditive effect on platelet secretion. Thus, granule labilization induced by PMA is a separable phenomenon and complementary to the effect of PGG2 on contraction. The ultimate degree of secretion is dependent on both processes. Studies using additional inhibitors supported the hypothesis that PGG2 activates platelets (either directly or following conversion to thromboxane A2) by transporting calcium from an intracellular store to the cytoplasmic site of the platelet contractile proteins." @default.
- W2297805513 created "2016-06-24" @default.
- W2297805513 creator A5024513943 @default.
- W2297805513 creator A5044257940 @default.
- W2297805513 creator A5064279789 @default.
- W2297805513 creator A5084481781 @default.
- W2297805513 creator A5091494736 @default.
- W2297805513 date "1977-01-01" @default.
- W2297805513 modified "2023-09-23" @default.
- W2297805513 title "The influence of prostaglandin G2 on platelet ultrastructure and platelet secretion." @default.
- W2297805513 cites W125678577 @default.
- W2297805513 cites W185829051 @default.
- W2297805513 cites W192727935 @default.
- W2297805513 cites W1971065866 @default.
- W2297805513 cites W1971580425 @default.
- W2297805513 cites W2010694924 @default.
- W2297805513 cites W2013555475 @default.
- W2297805513 cites W2024478054 @default.
- W2297805513 cites W2030087792 @default.
- W2297805513 cites W2036537484 @default.
- W2297805513 cites W2038811742 @default.
- W2297805513 cites W2043580911 @default.
- W2297805513 cites W2050568232 @default.
- W2297805513 cites W2061296910 @default.
- W2297805513 cites W2068483361 @default.
- W2297805513 cites W2072581723 @default.
- W2297805513 cites W2092803861 @default.
- W2297805513 cites W2145412799 @default.
- W2297805513 cites W2225715999 @default.
- W2297805513 cites W2239163925 @default.
- W2297805513 cites W233456458 @default.
- W2297805513 cites W2396016867 @default.
- W2297805513 cites W2422948437 @default.
- W2297805513 cites W2466880197 @default.
- W2297805513 cites W308614014 @default.
- W2297805513 cites W32226917 @default.
- W2297805513 cites W329883 @default.
- W2297805513 cites W62728581 @default.
- W2297805513 cites W1735876665 @default.
- W2297805513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2032055" @default.
- W2297805513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/188341" @default.
- W2297805513 hasPublicationYear "1977" @default.
- W2297805513 type Work @default.
- W2297805513 sameAs 2297805513 @default.
- W2297805513 citedByCount "17" @default.
- W2297805513 countsByYear W22978055132015 @default.
- W2297805513 crossrefType "journal-article" @default.
- W2297805513 hasAuthorship W2297805513A5024513943 @default.
- W2297805513 hasAuthorship W2297805513A5044257940 @default.
- W2297805513 hasAuthorship W2297805513A5064279789 @default.
- W2297805513 hasAuthorship W2297805513A5084481781 @default.
- W2297805513 hasAuthorship W2297805513A5091494736 @default.
- W2297805513 hasConcept C126322002 @default.
- W2297805513 hasConcept C134018914 @default.
- W2297805513 hasConcept C151730666 @default.
- W2297805513 hasConcept C163415756 @default.
- W2297805513 hasConcept C185592680 @default.
- W2297805513 hasConcept C190062978 @default.
- W2297805513 hasConcept C2780664492 @default.
- W2297805513 hasConcept C2781024287 @default.
- W2297805513 hasConcept C2781295650 @default.
- W2297805513 hasConcept C3018697912 @default.
- W2297805513 hasConcept C49039625 @default.
- W2297805513 hasConcept C49760210 @default.
- W2297805513 hasConcept C519063684 @default.
- W2297805513 hasConcept C55493867 @default.
- W2297805513 hasConcept C71924100 @default.
- W2297805513 hasConcept C79879829 @default.
- W2297805513 hasConcept C86803240 @default.
- W2297805513 hasConcept C89560881 @default.
- W2297805513 hasConceptScore W2297805513C126322002 @default.
- W2297805513 hasConceptScore W2297805513C134018914 @default.
- W2297805513 hasConceptScore W2297805513C151730666 @default.
- W2297805513 hasConceptScore W2297805513C163415756 @default.
- W2297805513 hasConceptScore W2297805513C185592680 @default.
- W2297805513 hasConceptScore W2297805513C190062978 @default.
- W2297805513 hasConceptScore W2297805513C2780664492 @default.
- W2297805513 hasConceptScore W2297805513C2781024287 @default.
- W2297805513 hasConceptScore W2297805513C2781295650 @default.
- W2297805513 hasConceptScore W2297805513C3018697912 @default.
- W2297805513 hasConceptScore W2297805513C49039625 @default.
- W2297805513 hasConceptScore W2297805513C49760210 @default.
- W2297805513 hasConceptScore W2297805513C519063684 @default.
- W2297805513 hasConceptScore W2297805513C55493867 @default.
- W2297805513 hasConceptScore W2297805513C71924100 @default.
- W2297805513 hasConceptScore W2297805513C79879829 @default.
- W2297805513 hasConceptScore W2297805513C86803240 @default.
- W2297805513 hasConceptScore W2297805513C89560881 @default.
- W2297805513 hasIssue "1" @default.
- W2297805513 hasLocation W22978055131 @default.
- W2297805513 hasOpenAccess W2297805513 @default.
- W2297805513 hasPrimaryLocation W22978055131 @default.
- W2297805513 hasRelatedWork W1970078269 @default.
- W2297805513 hasRelatedWork W2012922704 @default.
- W2297805513 hasRelatedWork W2086193984 @default.
- W2297805513 hasRelatedWork W2089342784 @default.
- W2297805513 hasRelatedWork W2171267045 @default.
- W2297805513 hasRelatedWork W2285325849 @default.