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- W2297814924 abstract "In the two past decades, a number of communications, case-control studies, and retrospective reports have appeared in the literature with concerns about the development of a complex set of clinical, laboratory and histological characteristics of a liver graft dysfunction that is compatible with autoimmune hepatitis. The de novo prefix was added to distinguish this entity from a pre-transplant primary autoimmune hepatitis, but the globally accepted criteria for the diagnosis of autoimmune hepatitis have been adopted in the diagnostic algorithm. Indeed, de novo autoimmune hepatitis is characterized by the typical liver necro-inflammation that is rich in plasma cells, the presence of interface hepatitis and the consequent laboratory findings of elevations in liver enzymes, increases in serum gamma globulin and the appearance of non-organ specific auto-antibodies. Still, the overall features of de novo autoimmune hepatitis appear not to be attributable to a univocal patho-physiological pathway because they can develop in the patients who have undergone liver transplantation due to different etiologies. Specifically, in subjects with hepatitis C virus recurrence, an interferon-containing antiviral treatment has been indicated as a potential inception of immune system derangement. Herein, we attempt to review the currently available knowledge about de novo liver autoimmunity and its clinical management." @default.
- W2297814924 created "2016-06-24" @default.
- W2297814924 creator A5029075217 @default.
- W2297814924 creator A5061878594 @default.
- W2297814924 creator A5062155863 @default.
- W2297814924 creator A5070138170 @default.
- W2297814924 creator A5079443706 @default.
- W2297814924 date "2016-01-01" @default.
- W2297814924 modified "2023-10-01" @default.
- W2297814924 title "<i>De novo</i>autoimmune hepatitis in liver transplant: State-of-the-art review" @default.
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- W2297814924 doi "https://doi.org/10.3748/wjg.v22.i10.2906" @default.
- W2297814924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4779914" @default.
- W2297814924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26973387" @default.
- W2297814924 hasPublicationYear "2016" @default.