FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297819692> ?p ?o ?g. }

• W2297819692 endingPage "78" @default.
• W2297819692 startingPage "68" @default.
• W2297819692 abstract "Fluoxetine, a selective serotonin reuptake inhibitor, exerts neuroprotective effects in a variety of neurological diseases including stroke, but the underlying mechanism remains obscure. In the present study, we addressed the molecular events in fluoxetine against ischemia/reperfusion-induced acute neuronal injury and inflammation-induced neuronal apoptosis. We showed that treatment of fluoxetine (40 mg/kg, i.p.) with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tMCAO) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (IL-1β), Bax and p53 expression and upregulating anti-apoptotic protein Bcl-2 level. We next mimicked neuroinflammation in ischemic stroke with IL-1β in primary cultured cortical neurons and found that pretreatment with fluoxetine (1 μM) prevented IL-1β-induced neuronal apoptosis and upregulation of p53 expression. Furthermore, we demonstrated that p53 overexpression in N2a cell line abolished the anti-apoptotic effect of fluoxetine, indicating that p53 downregulation is required for the protective role of fluoxetine in IL-1β-induced neuronal apoptosis. Fluoxetine downregulating p53 expression could be mimicked by SB203580, a specific inhibitor of p38, but blocked by anisomycin, a p38 activator. Collectively, our findings have revealed that fluoxetine protects against IL-1β-induced neuronal apoptosis via p38-p53 dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke." @default.
• W2297819692 created "2016-06-24" @default.
• W2297819692 creator A5013586047 @default.
• W2297819692 creator A5020189934 @default.
• W2297819692 creator A5032240816 @default.
• W2297819692 creator A5057523750 @default.
• W2297819692 creator A5057760320 @default.
• W2297819692 creator A5062324929 @default.
• W2297819692 creator A5073777282 @default.
• W2297819692 creator A5085243615 @default.
• W2297819692 creator A5088581766 @default.
• W2297819692 date "2016-08-01" @default.
• W2297819692 modified "2023-10-12" @default.
• W2297819692 title "Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53" @default.
• W2297819692 cites W1526979969 @default.
• W2297819692 cites W1573571633 @default.
• W2297819692 cites W1583501533 @default.
• W2297819692 cites W1799639810 @default.
• W2297819692 cites W1813521438 @default.
• W2297819692 cites W1852601285 @default.
• W2297819692 cites W1962010571 @default.
• W2297819692 cites W1966064561 @default.
• W2297819692 cites W1988512597 @default.
• W2297819692 cites W1994394172 @default.
• W2297819692 cites W2011115200 @default.
• W2297819692 cites W2016827447 @default.
• W2297819692 cites W2021600310 @default.
• W2297819692 cites W2021727661 @default.
• W2297819692 cites W2023236768 @default.
• W2297819692 cites W2032338900 @default.
• W2297819692 cites W2034133293 @default.
• W2297819692 cites W2043915678 @default.
• W2297819692 cites W2052016589 @default.
• W2297819692 cites W2053477778 @default.
• W2297819692 cites W2066189463 @default.
• W2297819692 cites W2070614971 @default.
• W2297819692 cites W2074125037 @default.
• W2297819692 cites W2074950378 @default.
• W2297819692 cites W2080856095 @default.
• W2297819692 cites W2081261126 @default.
• W2297819692 cites W2084208567 @default.
• W2297819692 cites W2093289135 @default.
• W2297819692 cites W2096695840 @default.
• W2297819692 cites W2104449396 @default.
• W2297819692 cites W2107281979 @default.
• W2297819692 cites W2113352586 @default.
• W2297819692 cites W2126270462 @default.
• W2297819692 cites W2134804946 @default.
• W2297819692 cites W2134887638 @default.
• W2297819692 cites W2142299995 @default.
• W2297819692 cites W2144106732 @default.
• W2297819692 cites W2152221123 @default.
• W2297819692 cites W2163185069 @default.
• W2297819692 cites W2167153356 @default.
• W2297819692 cites W2181566246 @default.
• W2297819692 cites W2189117537 @default.
• W2297819692 cites W2210218255 @default.
• W2297819692 cites W2431147098 @default.
• W2297819692 doi "https://doi.org/10.1016/j.neuropharm.2016.03.019" @default.
• W2297819692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26976669" @default.
• W2297819692 hasPublicationYear "2016" @default.
• W2297819692 type Work @default.
• W2297819692 sameAs 2297819692 @default.
• W2297819692 citedByCount "34" @default.
• W2297819692 countsByYear W22978196922016 @default.
• W2297819692 countsByYear W22978196922017 @default.
• W2297819692 countsByYear W22978196922018 @default.
• W2297819692 countsByYear W22978196922019 @default.
• W2297819692 countsByYear W22978196922020 @default.
• W2297819692 countsByYear W22978196922021 @default.
• W2297819692 countsByYear W22978196922022 @default.
• W2297819692 countsByYear W22978196922023 @default.
• W2297819692 crossrefType "journal-article" @default.
• W2297819692 hasAuthorship W2297819692A5013586047 @default.
• W2297819692 hasAuthorship W2297819692A5020189934 @default.
• W2297819692 hasAuthorship W2297819692A5032240816 @default.
• W2297819692 hasAuthorship W2297819692A5057523750 @default.
• W2297819692 hasAuthorship W2297819692A5057760320 @default.
• W2297819692 hasAuthorship W2297819692A5062324929 @default.
• W2297819692 hasAuthorship W2297819692A5073777282 @default.
• W2297819692 hasAuthorship W2297819692A5085243615 @default.
• W2297819692 hasAuthorship W2297819692A5088581766 @default.
• W2297819692 hasConcept C104317684 @default.
• W2297819692 hasConcept C126322002 @default.
• W2297819692 hasConcept C127561419 @default.
• W2297819692 hasConcept C170493617 @default.
• W2297819692 hasConcept C185592680 @default.
• W2297819692 hasConcept C190283241 @default.
• W2297819692 hasConcept C25498285 @default.
• W2297819692 hasConcept C2775864247 @default.
• W2297819692 hasConcept C2776134451 @default.
• W2297819692 hasConcept C2776914184 @default.
• W2297819692 hasConcept C51551487 @default.
• W2297819692 hasConcept C55493867 @default.
• W2297819692 hasConcept C57074206 @default.
• W2297819692 hasConcept C62478195 @default.
• W2297819692 hasConcept C71924100 @default.
• W2297819692 hasConcept C86803240 @default.

• next