FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297872912> ?p ?o ?g. }

• W2297872912 endingPage "1878" @default.
• W2297872912 startingPage "1871" @default.
• W2297872912 abstract "Aerobic glycolysis and lactate production in the brain plays a key role in memory, yet the role of this metabolism in the cognitive decline associated with Alzheimer's disease (AD) remains poorly understood. Here we examined the relationship between cerebral lactate levels and memory performance in an APP/PS1 mouse model of AD, which progressively accumulates amyloid-β. In vivo 1 H-magnetic resonance spectroscopy revealed an age-dependent decline in lactate levels within the frontal cortex of control mice, whereas lactate levels remained unaltered in APP/PS1 mice from 3 to 12 months of age. Analysis of hippocampal interstitial fluid by in vivo microdialysis revealed a significant elevation in lactate levels in APP/PS1 mice relative to control mice at 12 months of age. An age-dependent decline in the levels of key aerobic glycolysis enzymes and a concomitant increase in lactate transporter expression was detected in control mice. Increased expression of lactate-producing enzymes correlated with improved memory in control mice. Interestingly, in APP/PS1 mice the opposite effect was detected. In these mice, increased expression of lactate producing enzymes correlated with poorer memory performance. Immunofluorescent staining revealed localization of the aerobic glycolysis enzymes pyruvate dehydrogenase kinase and lactate dehydrogenase A within cortical and hippocampal neurons in control mice, as well as within astrocytes surrounding amyloid plaques in APP/PS1 mice. These observations collectively indicate that production of lactate, via aerobic glycolysis, is beneficial for memory function during normal aging. However, elevated lactate levels in APP/PS1 mice indicate perturbed lactate processing, a factor that may contribute to cognitive decline in AD. SIGNIFICANCE STATEMENT Lactate has recently emerged as a key metabolite necessary for memory consolidation. Lactate is the end product of aerobic glycolysis, a unique form of metabolism that occurs within certain regions of the brain. Here we detected an age-dependent decline in the expression of aerobic glycolysis enzymes and a concomitant decrease in lactate levels within the frontal cortex of wild-type mice. Improved memory performance in wild-type mice correlated with elevated expression of aerobic glycolysis enzymes. Surprisingly, lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP/PS1 mice. These findings suggest that while lactate production is beneficial for memory in the healthy aging brain, it might be detrimental in an Alzheimer's disease context." @default.
• W2297872912 created "2016-06-24" @default.
• W2297872912 creator A5011479336 @default.
• W2297872912 creator A5011579867 @default.
• W2297872912 creator A5016604588 @default.
• W2297872912 creator A5041379300 @default.
• W2297872912 creator A5059994803 @default.
• W2297872912 creator A5061478670 @default.
• W2297872912 creator A5066821454 @default.
• W2297872912 creator A5071774128 @default.
• W2297872912 creator A5088998527 @default.
• W2297872912 date "2016-02-10" @default.
• W2297872912 modified "2023-10-14" @default.
• W2297872912 title "Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis" @default.
• W2297872912 cites W1623967253 @default.
• W2297872912 cites W1797578063 @default.
• W2297872912 cites W1967757301 @default.
• W2297872912 cites W1968894006 @default.
• W2297872912 cites W1975141413 @default.
• W2297872912 cites W1993303421 @default.
• W2297872912 cites W2001725826 @default.
• W2297872912 cites W2014199129 @default.
• W2297872912 cites W2014988592 @default.
• W2297872912 cites W2021519230 @default.
• W2297872912 cites W2021965016 @default.
• W2297872912 cites W2029205073 @default.
• W2297872912 cites W2041562324 @default.
• W2297872912 cites W2046181551 @default.
• W2297872912 cites W2058020816 @default.
• W2297872912 cites W2065230229 @default.
• W2297872912 cites W2073268517 @default.
• W2297872912 cites W2073781183 @default.
• W2297872912 cites W2088262785 @default.
• W2297872912 cites W2095987251 @default.
• W2297872912 cites W2098685543 @default.
• W2297872912 cites W2103106576 @default.
• W2297872912 cites W2116298307 @default.
• W2297872912 cites W2130943278 @default.
• W2297872912 cites W2137243283 @default.
• W2297872912 cites W2145812954 @default.
• W2297872912 cites W2157526951 @default.
• W2297872912 cites W2169473035 @default.
• W2297872912 doi "https://doi.org/10.1523/jneurosci.3131-15.2016" @default.
• W2297872912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4748073" @default.
• W2297872912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26865611" @default.
• W2297872912 hasPublicationYear "2016" @default.
• W2297872912 type Work @default.
• W2297872912 sameAs 2297872912 @default.
• W2297872912 citedByCount "61" @default.
• W2297872912 countsByYear W22978729122016 @default.
• W2297872912 countsByYear W22978729122017 @default.
• W2297872912 countsByYear W22978729122018 @default.
• W2297872912 countsByYear W22978729122019 @default.
• W2297872912 countsByYear W22978729122020 @default.
• W2297872912 countsByYear W22978729122021 @default.
• W2297872912 countsByYear W22978729122022 @default.
• W2297872912 countsByYear W22978729122023 @default.
• W2297872912 crossrefType "journal-article" @default.
• W2297872912 hasAuthorship W2297872912A5011479336 @default.
• W2297872912 hasAuthorship W2297872912A5011579867 @default.
• W2297872912 hasAuthorship W2297872912A5016604588 @default.
• W2297872912 hasAuthorship W2297872912A5041379300 @default.
• W2297872912 hasAuthorship W2297872912A5059994803 @default.
• W2297872912 hasAuthorship W2297872912A5061478670 @default.
• W2297872912 hasAuthorship W2297872912A5066821454 @default.
• W2297872912 hasAuthorship W2297872912A5071774128 @default.
• W2297872912 hasAuthorship W2297872912A5088998527 @default.
• W2297872912 hasBestOaLocation W22978729121 @default.
• W2297872912 hasConcept C102230213 @default.
• W2297872912 hasConcept C104317684 @default.
• W2297872912 hasConcept C126322002 @default.
• W2297872912 hasConcept C134018914 @default.
• W2297872912 hasConcept C141035611 @default.
• W2297872912 hasConcept C148762608 @default.
• W2297872912 hasConcept C150903083 @default.
• W2297872912 hasConcept C181199279 @default.
• W2297872912 hasConcept C185592680 @default.
• W2297872912 hasConcept C20251656 @default.
• W2297872912 hasConcept C207001950 @default.
• W2297872912 hasConcept C2777318727 @default.
• W2297872912 hasConcept C2780854706 @default.
• W2297872912 hasConcept C2781161787 @default.
• W2297872912 hasConcept C28406088 @default.
• W2297872912 hasConcept C2910680157 @default.
• W2297872912 hasConcept C50156730 @default.
• W2297872912 hasConcept C529278444 @default.
• W2297872912 hasConcept C55493867 @default.
• W2297872912 hasConcept C55885012 @default.
• W2297872912 hasConcept C62231903 @default.
• W2297872912 hasConcept C71924100 @default.
• W2297872912 hasConcept C86803240 @default.
• W2297872912 hasConceptScore W2297872912C102230213 @default.
• W2297872912 hasConceptScore W2297872912C104317684 @default.
• W2297872912 hasConceptScore W2297872912C126322002 @default.
• W2297872912 hasConceptScore W2297872912C134018914 @default.
• W2297872912 hasConceptScore W2297872912C141035611 @default.
• W2297872912 hasConceptScore W2297872912C148762608 @default.
• W2297872912 hasConceptScore W2297872912C150903083 @default.

• next