Matches in SemOpenAlex for { <https://semopenalex.org/work/W2297875105> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2297875105 endingPage "84" @default.
- W2297875105 startingPage "43" @default.
- W2297875105 abstract "Quercetin is the major representative of the flavonoid subclass of flavonols. Due to its anti-oxidant, anti-tumor and anti-inflammatory activity, quercetin has been studied extensively as a chemopreventive agent in several cancer models. Quercetin has been shown to inhibit proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. In addition, our studies and those by others showed that quercetin could „sensitize“ cancer cells to chemotherapeutic agents, likely by blocking NF-kappaB activation induced by chemotherapeutic agents both in vitro and in vivo. Furthermore, pretreatment with quercetin sensitizes cancer cells to growth inhibition and apoptosis induced by chemotherapeutic agents. By inhibiting P-glycoprotein 1 (P-gp) activity, quercetin also increases the accumulation of chemotherapeutics in P-gp expressing cancer cells which results in altered absorption/bioavailability of these drugs after coadministration with quercetin. These results provide experimental evidence that novel therapeutic strategies for human cancer could be developed to achieve better treatment outcome by introducing flavonoid quercetin in the therapeutic regimen. In an effort to improve local tumor control, a multimodality treatment strategy including regional hyperthermia (RHT), chemotherapy and immunomodulation with quercetin, seems to be very attractive in the treatment of various tumors. The rationale for the combination of cytotoxic drugs with hyperthermia in the treatment of tumor is based on experimental evidence that heat exposure increases the killing of tumor cells by direct thermal cytotoxicity and is able to sensitize perfused tumor tissue towards chemotherapy in a synergistic manner. Hyperthermia combined with conventional chemotherapy has meanwhile been integrated in multimodality treatment strategies for various tumors. Hyperthermia is a promising approach for cancer therapy because it not only kills cancer cells directly, but also activates anti-cancer immunity as an indirect effect. In addition, hyperthermia enhances the clastogenicity of alkylating agents. The objective of our study was to see whether pretreatment with quercetin could enhance the cytotoxic and apoptotic effect of commonly used chemotherapeutic agents or radiation for the treatment of different tumors. In addition, we determined whether quercetin has the potential to serve as a beneficial supplement before hyperthermal intraperitoneal chemotherapy (HIPEC) and whether quercetin can reduce clastogenic effect of cisplatin, irinotecan and other chemoterapeutics on healthy tissue in mice bearing tumor. These aspects of quercetin are discussed further in detail in this review." @default.
- W2297875105 created "2016-06-24" @default.
- W2297875105 creator A5035333815 @default.
- W2297875105 creator A5057474634 @default.
- W2297875105 date "2015-01-01" @default.
- W2297875105 modified "2023-09-28" @default.
- W2297875105 title "Multimodal Approach to Tumor Therapy with Quercetin, Chemotherapy, Radiotherapy and Hyperthermia" @default.
- W2297875105 hasPublicationYear "2015" @default.
- W2297875105 type Work @default.
- W2297875105 sameAs 2297875105 @default.
- W2297875105 citedByCount "0" @default.
- W2297875105 crossrefType "journal-article" @default.
- W2297875105 hasAuthorship W2297875105A5035333815 @default.
- W2297875105 hasAuthorship W2297875105A5057474634 @default.
- W2297875105 hasConcept C109316439 @default.
- W2297875105 hasConcept C121608353 @default.
- W2297875105 hasConcept C126322002 @default.
- W2297875105 hasConcept C150903083 @default.
- W2297875105 hasConcept C185592680 @default.
- W2297875105 hasConcept C190283241 @default.
- W2297875105 hasConcept C202751555 @default.
- W2297875105 hasConcept C207001950 @default.
- W2297875105 hasConcept C2776694085 @default.
- W2297875105 hasConcept C2778004101 @default.
- W2297875105 hasConcept C2779054382 @default.
- W2297875105 hasConcept C2779949491 @default.
- W2297875105 hasConcept C2780394083 @default.
- W2297875105 hasConcept C2781263971 @default.
- W2297875105 hasConcept C502942594 @default.
- W2297875105 hasConcept C55493867 @default.
- W2297875105 hasConcept C71924100 @default.
- W2297875105 hasConcept C86803240 @default.
- W2297875105 hasConcept C96232424 @default.
- W2297875105 hasConcept C98274493 @default.
- W2297875105 hasConceptScore W2297875105C109316439 @default.
- W2297875105 hasConceptScore W2297875105C121608353 @default.
- W2297875105 hasConceptScore W2297875105C126322002 @default.
- W2297875105 hasConceptScore W2297875105C150903083 @default.
- W2297875105 hasConceptScore W2297875105C185592680 @default.
- W2297875105 hasConceptScore W2297875105C190283241 @default.
- W2297875105 hasConceptScore W2297875105C202751555 @default.
- W2297875105 hasConceptScore W2297875105C207001950 @default.
- W2297875105 hasConceptScore W2297875105C2776694085 @default.
- W2297875105 hasConceptScore W2297875105C2778004101 @default.
- W2297875105 hasConceptScore W2297875105C2779054382 @default.
- W2297875105 hasConceptScore W2297875105C2779949491 @default.
- W2297875105 hasConceptScore W2297875105C2780394083 @default.
- W2297875105 hasConceptScore W2297875105C2781263971 @default.
- W2297875105 hasConceptScore W2297875105C502942594 @default.
- W2297875105 hasConceptScore W2297875105C55493867 @default.
- W2297875105 hasConceptScore W2297875105C71924100 @default.
- W2297875105 hasConceptScore W2297875105C86803240 @default.
- W2297875105 hasConceptScore W2297875105C96232424 @default.
- W2297875105 hasConceptScore W2297875105C98274493 @default.
- W2297875105 hasLocation W22978751051 @default.
- W2297875105 hasOpenAccess W2297875105 @default.
- W2297875105 hasPrimaryLocation W22978751051 @default.
- W2297875105 hasRelatedWork W157656773 @default.
- W2297875105 hasRelatedWork W2025671634 @default.
- W2297875105 hasRelatedWork W2028492453 @default.
- W2297875105 hasRelatedWork W2047518382 @default.
- W2297875105 hasRelatedWork W2072549578 @default.
- W2297875105 hasRelatedWork W2103707167 @default.
- W2297875105 hasRelatedWork W2144880360 @default.
- W2297875105 hasRelatedWork W2164164886 @default.
- W2297875105 hasRelatedWork W2208031427 @default.
- W2297875105 hasRelatedWork W2376959098 @default.
- W2297875105 hasRelatedWork W2416422602 @default.
- W2297875105 hasRelatedWork W2516619022 @default.
- W2297875105 hasRelatedWork W2562170297 @default.
- W2297875105 hasRelatedWork W2784964219 @default.
- W2297875105 hasRelatedWork W2810164816 @default.
- W2297875105 hasRelatedWork W2890217657 @default.
- W2297875105 hasRelatedWork W2918165631 @default.
- W2297875105 hasRelatedWork W3033084621 @default.
- W2297875105 hasRelatedWork W3149397781 @default.
- W2297875105 hasRelatedWork W2820225330 @default.
- W2297875105 isParatext "false" @default.
- W2297875105 isRetracted "false" @default.
- W2297875105 magId "2297875105" @default.
- W2297875105 workType "article" @default.