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- W2297890369 abstract "Background: In Mexico, AML survival is referred in 30%. Our aim was toevaluate results with ADE protocol as induction treatment in children withnon-M3 AML in a public Mexican institution. Method: We included patients withAML in a single institution between 2005 and 2013. All non-M3-AML patientsreceived ADE as induction therapy (cytarabine 100 mg/m2 in continuousinfusion from day 1 to 7, daunorrubicin 30 mg/m2 days 1, 3, 5 andetoposide 100 mg/m2 over days 1 to 5). Patients received antibioticprophylaxis and strict scheduled appointments to assure adherence and preventavoidable emergencies. Main Results: Eighteen patients were included. Medianage was 106 months. One patient died at diagnosis so 17 were eligible forinduction results analysis; eleven needed two cycles and six patients three.Remission rate was 100%. Analyzing non-M3 patients overall survival was 80.2%at 100 months. No fatal complications were observed. Stratifying by number of cycleswe observe that patients receiving one ADE cycle had a 0% overall survival atshort follow up, with 2 ADE cycles 80% at 100 months and with 3 cycles 100% at60 months. Conclusion: ADE induction therapy showed improved results in overallsurvival compared with other standard regimens. Following the protocol weobtained 100% remission. This is an important achievement in our population.Our focus must be to ameliorate maintenance final results. These results shouldbe reproduced in other hospitals in Mexico and other countries." @default.
- W2297890369 created "2016-06-24" @default.
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- W2297890369 date "2016-01-01" @default.
- W2297890369 modified "2023-10-17" @default.
- W2297890369 title "ADE as Induction Therapy Results in Treatment of Children with Non-M3 High-Risk Acute Myeloid Leukemia, an Extrapolable Achievement in Developing Countries" @default.
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- W2297890369 doi "https://doi.org/10.4236/jct.2016.73020" @default.
- W2297890369 hasPublicationYear "2016" @default.
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