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• W2297946226 abstract "SUMMARY We studied the prevalence of Helicobacter pylori virulence markers, e.g. cytotoxin associated gene ( cag A), cag A promoter, vacuolating associated cytotoxin A ( vac A) alleles induced by contact with epithelium ( ice A type), and outer membrane protein Q ( hop Q) in expatriates and compared them with those in local residents. Gastric biopsies were obtained at endoscopy for culture, histology and PCR for virulence marker and hop Q. Of 309 patients, 236 (76%) were males with a mean age of 45 years. A total of 102 patients were expatriates. hop Q type 1 was present in 98 (47%) local residents compared to 88 (86%) expatriates ( P < 0·001), while hop Q type 2 was present in 176 (85%) local residents, compared to 60 (59%) expatriates ( P < 0·001). H. pylori virulence marker cag A was positive in 97 (47%) local residents compared to 86 (84%) expatriates ( P < 0·001) while cag A-P was positive in 72 (35%) local residents compared to 87 (85%) expatriates ( P < 0·001). ice A type 1 was positive in 157 (76%) local residents compared to 45 (44%) expatriates ( P < 0·001), while ice A type 2 was positive in 81 (39%) local residents compared to 86 (84%) expatriates ( P < 0·001). Distribution of H. pylori cag A, cag A promoter, ice A and hop Q type in local residents and expatriates was different. H. pylori virulence markers were associated with severe pathology in expatriates." @default.
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• W2297946226 date "2016-03-04" @default.
• W2297946226 modified "2023-10-13" @default.
• W2297946226 title "<i>Helicobacter pylori</i> outer membrane protein and virulence marker differences in expatriate patients" @default.
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• W2297946226 doi "https://doi.org/10.1017/s095026881600025x" @default.
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