Matches in SemOpenAlex for { <https://semopenalex.org/work/W22979664> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W22979664 endingPage "261" @default.
- W22979664 startingPage "261" @default.
- W22979664 abstract "Objective: The present study investigates protective effect of hesperidin on streptozotocin and high fat diet induced diabetic nephropathy in experimental type 2 diabetic rats. Methods: Sprague Dawley rats were fed with high fat emulsion and high fat diet for 2 weeks to induce glucose intolerance and then injected with streptozotocin (35 mg/kg, i.p.). Following 48 h of streptozotocin injection blood glucose level was estimated to confirm hyperglycemia. After 4 weeks of diabetes induction diabetic rats were orally treated with hesperidin (50, 100 and 200 mg/kg body weight) for 4 weeks. At the end of the treatment kidney functions, oxidative stress indices, biochemical estimations and histopathological examination were carried out to assess the efficacy of the treatment. Results: Diabetic rats exhibited significant rise in blood glucose level, altered kidney functions, oxidative stress and histological abnormalities compared to control rats. Hesperidin treatment significantly reduced the elevated levels of blood glucose, creatinine, urea nitrogen, total cholesterol and triglyceride when compared with diabetic control rats. Significant rise in renal hypertrophy, hyperfiltration, microalbuminuria as well as oxidative stress in the diabetic rats were effectively attenuated with hesperidin treatment, dose dependently. Moreover, basement membrane thickening and mesangial expansion observed in the kidney of diabetic rats restored near to normal structure. Conclusion: Results of the present study suggest that hesperidin ameliorate early diabetic nephropathy." @default.
- W22979664 created "2016-06-24" @default.
- W22979664 creator A5019708544 @default.
- W22979664 creator A5078673250 @default.
- W22979664 date "2014-01-01" @default.
- W22979664 modified "2023-09-26" @default.
- W22979664 title "Hesperidin ameliorates streptozotocin and high fat diet induced diabetic nephropathy in rats" @default.
- W22979664 doi "https://doi.org/10.5455/jeim.010814.or.108" @default.
- W22979664 hasPublicationYear "2014" @default.
- W22979664 type Work @default.
- W22979664 sameAs 22979664 @default.
- W22979664 citedByCount "4" @default.
- W22979664 countsByYear W229796642017 @default.
- W22979664 countsByYear W229796642018 @default.
- W22979664 countsByYear W229796642019 @default.
- W22979664 countsByYear W229796642022 @default.
- W22979664 crossrefType "journal-article" @default.
- W22979664 hasAuthorship W22979664A5019708544 @default.
- W22979664 hasAuthorship W22979664A5078673250 @default.
- W22979664 hasConcept C134018914 @default.
- W22979664 hasConcept C142724271 @default.
- W22979664 hasConcept C204787440 @default.
- W22979664 hasConcept C2776128092 @default.
- W22979664 hasConcept C2779280383 @default.
- W22979664 hasConcept C2779922275 @default.
- W22979664 hasConcept C555293320 @default.
- W22979664 hasConcept C556039675 @default.
- W22979664 hasConcept C71924100 @default.
- W22979664 hasConceptScore W22979664C134018914 @default.
- W22979664 hasConceptScore W22979664C142724271 @default.
- W22979664 hasConceptScore W22979664C204787440 @default.
- W22979664 hasConceptScore W22979664C2776128092 @default.
- W22979664 hasConceptScore W22979664C2779280383 @default.
- W22979664 hasConceptScore W22979664C2779922275 @default.
- W22979664 hasConceptScore W22979664C555293320 @default.
- W22979664 hasConceptScore W22979664C556039675 @default.
- W22979664 hasConceptScore W22979664C71924100 @default.
- W22979664 hasIssue "4" @default.
- W22979664 hasLocation W229796641 @default.
- W22979664 hasOpenAccess W22979664 @default.
- W22979664 hasPrimaryLocation W229796641 @default.
- W22979664 hasRelatedWork W1563850031 @default.
- W22979664 hasRelatedWork W1566399807 @default.
- W22979664 hasRelatedWork W1979172403 @default.
- W22979664 hasRelatedWork W2042543610 @default.
- W22979664 hasRelatedWork W2064642002 @default.
- W22979664 hasRelatedWork W2086814303 @default.
- W22979664 hasRelatedWork W22979664 @default.
- W22979664 hasRelatedWork W2373552354 @default.
- W22979664 hasRelatedWork W2760813744 @default.
- W22979664 hasRelatedWork W2768848330 @default.
- W22979664 hasVolume "4" @default.
- W22979664 isParatext "false" @default.
- W22979664 isRetracted "false" @default.
- W22979664 magId "22979664" @default.
- W22979664 workType "article" @default.