FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298014760> ?p ?o ?g. }

• W2298014760 endingPage "15" @default.
• W2298014760 startingPage "907" @default.
• W2298014760 abstract "Aspirin use is known to reduce the recurrence of stroke. However, the clinical response to aspirin has been mixed. The rate of stroke recurrence whilst on aspirin treatment is still unacceptably high. A plausible explanation for this may be resistance to the effects of aspirin. The causes of aspirin resistance are manifold and multi-factorial. We conducted a study to investigate the prevalence rate of biochemical aspirin resistance in a cohort of aspirin-naïve stroke patients. We also sought to determine the inherent factors that may predispose towards the development of aspirin resistance.This was a cross-sectional, observational study conducted on patients admitted to our centre with an acute stroke who were aspirin-naïve. The diagnosis of an acute stroke was confirmed by clinical history and brain imaging. Fifty consecutive patients were prospectively enrolled. Socio-demographic data were collected and baseline blood investigations were performed. Patients were tested for biochemical aspirin resistance using Multiplate platelet analyser (Dynabyte, Munich, Germany) after 5 doses of aspirin, corresponding to a total dose of 900 mg.The median age of patients was 65.5 years and 54 % of patients were female. There were 11 smokers; of these 10 were male. Twenty-six (52 %) patients were Chinese, 21 (41 %) were Malay and 3 (6.0 %) were Indian. Aspirin resistance was present in 14 % of our patients. There was an inverse relationship between the presence of aspirin resistance and plasma HDL levels (r = -0.394; p = 0.005). There was no relationship observed between aspirin resistance and total cholesterol, triglycerides, LDL, HbA1c, ALT, ALP, urea and creatinine levels. There were no significant differences in demographic profiles or smoking status between the aspirin resistant and non-aspirin resistant groups. We did not find any link between ethnicity and aspirin resistance.Our results indicate that a lower HDL level is associated with biochemical aspirin resistance. This may increase platelet aggregation and consequently increase the risk of a recurrent stroke. The clinical implications for aspirin resistance are far reaching. Any evidence that correctable factors may negatively influence the action of aspirin warrants further investigation. The prevalence rate of biochemical aspirin resistance in our study is comparable to the findings in other studies performed in an Asian population. Further research is required to determine how our findings translate into clinical aspirin resistance and stroke recurrence." @default.
• W2298014760 created "2016-06-24" @default.
• W2298014760 creator A5017965063 @default.
• W2298014760 creator A5020099557 @default.
• W2298014760 creator A5021454413 @default.
• W2298014760 creator A5022342044 @default.
• W2298014760 creator A5023126580 @default.
• W2298014760 creator A5048271779 @default.
• W2298014760 creator A5076034322 @default.
• W2298014760 creator A5076873364 @default.
• W2298014760 creator A5087277844 @default.
• W2298014760 date "2013-01-01" @default.
• W2298014760 modified "2023-10-01" @default.
• W2298014760 title "Biochemical aspirin resistance in stroke patients - a cross-sectional single centre study." @default.
• W2298014760 cites W1480729244 @default.
• W2298014760 cites W149587663 @default.
• W2298014760 cites W1988143463 @default.
• W2298014760 cites W1989615944 @default.
• W2298014760 cites W1996256445 @default.
• W2298014760 cites W2005882777 @default.
• W2298014760 cites W2007675502 @default.
• W2298014760 cites W2011941025 @default.
• W2298014760 cites W2019823288 @default.
• W2298014760 cites W2023520096 @default.
• W2298014760 cites W2035407396 @default.
• W2298014760 cites W2039408100 @default.
• W2298014760 cites W2042232724 @default.
• W2298014760 cites W2046066512 @default.
• W2298014760 cites W2048412312 @default.
• W2298014760 cites W2048760408 @default.
• W2298014760 cites W2063333355 @default.
• W2298014760 cites W2070200806 @default.
• W2298014760 cites W2078103827 @default.
• W2298014760 cites W2095631860 @default.
• W2298014760 cites W2096029390 @default.
• W2298014760 cites W2102191497 @default.
• W2298014760 cites W2107933782 @default.
• W2298014760 cites W2115830594 @default.
• W2298014760 cites W2133979871 @default.
• W2298014760 cites W2155895134 @default.
• W2298014760 cites W2161043271 @default.
• W2298014760 cites W2329338552 @default.
• W2298014760 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4827586" @default.
• W2298014760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27092036" @default.
• W2298014760 hasPublicationYear "2013" @default.
• W2298014760 type Work @default.
• W2298014760 sameAs 2298014760 @default.
• W2298014760 citedByCount "4" @default.
• W2298014760 countsByYear W22980147602017 @default.
• W2298014760 countsByYear W22980147602020 @default.
• W2298014760 countsByYear W22980147602021 @default.
• W2298014760 countsByYear W22980147602022 @default.
• W2298014760 crossrefType "journal-article" @default.
• W2298014760 hasAuthorship W2298014760A5017965063 @default.
• W2298014760 hasAuthorship W2298014760A5020099557 @default.
• W2298014760 hasAuthorship W2298014760A5021454413 @default.
• W2298014760 hasAuthorship W2298014760A5022342044 @default.
• W2298014760 hasAuthorship W2298014760A5023126580 @default.
• W2298014760 hasAuthorship W2298014760A5048271779 @default.
• W2298014760 hasAuthorship W2298014760A5076034322 @default.
• W2298014760 hasAuthorship W2298014760A5076873364 @default.
• W2298014760 hasAuthorship W2298014760A5087277844 @default.
• W2298014760 hasConcept C126322002 @default.
• W2298014760 hasConcept C127413603 @default.
• W2298014760 hasConcept C142052008 @default.
• W2298014760 hasConcept C142724271 @default.
• W2298014760 hasConcept C2777628954 @default.
• W2298014760 hasConcept C2780645631 @default.
• W2298014760 hasConcept C71924100 @default.
• W2298014760 hasConcept C78519656 @default.
• W2298014760 hasConceptScore W2298014760C126322002 @default.
• W2298014760 hasConceptScore W2298014760C127413603 @default.
• W2298014760 hasConceptScore W2298014760C142052008 @default.
• W2298014760 hasConceptScore W2298014760C142724271 @default.
• W2298014760 hasConceptScore W2298014760C2777628954 @default.
• W2298014760 hasConceptScore W2298014760C2780645631 @default.
• W2298014760 hasConceptScore W2298014760C71924100 @default.
• W2298014760 hasConceptScore W2298014760C78519656 @default.
• W2298014760 hasLocation W22980147601 @default.
• W2298014760 hasOpenAccess W2298014760 @default.
• W2298014760 hasPrimaryLocation W22980147601 @default.
• W2298014760 hasRelatedWork W1974083550 @default.
• W2298014760 hasRelatedWork W2008943972 @default.
• W2298014760 hasRelatedWork W2131430171 @default.
• W2298014760 hasRelatedWork W2366434335 @default.
• W2298014760 hasRelatedWork W2367823310 @default.
• W2298014760 hasRelatedWork W2737554635 @default.
• W2298014760 hasRelatedWork W2973841278 @default.
• W2298014760 hasRelatedWork W3198883042 @default.
• W2298014760 hasRelatedWork W4241944220 @default.
• W2298014760 hasRelatedWork W4255203891 @default.
• W2298014760 hasVolume "12" @default.
• W2298014760 isParatext "false" @default.
• W2298014760 isRetracted "false" @default.
• W2298014760 magId "2298014760" @default.
• W2298014760 workType "article" @default.