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- W2298169611 abstract "SOCS proteins are regulators of various signaltransduction cascades that are essential to normalphysiology. Important advances have been made inunderstanding their mode of action. However,unresolved issues include the involvement of SOCS inthe modulation of specific pathways and themechanisms controlling stability and regulation ofthese proteins. The importance of this isunderscored by the contribution of inappropriatelyregulated SOCS activity to several pathologiesincluding cancer and inflammatory diseases.This work provides further insights in the role ofSOCS proteins in different signalling pathways suchas leptin signal transduction. The hormone leptinemerged as a key player in body weight regulationbut it also has peripheral effects on diverse bodyfunctions. In the second part of this book novelroles for the SOCS box domain in the cross-regulation of other SOCS proteins and in substratebinding are reported.This work should help to further understand themechanisms underlying SOCS actions. Undoubtedly,knowledge of how SOCS proteins are regulated maylead to development of potent therapeutic options inthe treatment of several disorders." @default.
- W2298169611 created "2016-06-24" @default.
- W2298169611 creator A5028859507 @default.
- W2298169611 date "2008-12-03" @default.
- W2298169611 modified "2023-09-23" @default.
- W2298169611 title "SOCS Proteins and Cytokine Signalling: The many Faces of the SOCS Box" @default.
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