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- W2298237029 abstract "Background: Finding an effective alternative topical agent for burn wound treatment is required for some patients who are not suitable for silver sulfadiazine (SSD) treatment because of allergic reactions, leukopenia, or ineffectiveness. Bismuth subgallate/ borneol, marketed as Suile^(TM) (Hedonist Biochemical Technologies Co., Ltd, Taipei, Taiwan), is FDA approved for certain wounds including first and second-degree burns. The relative effectiveness of Suile^(TM) versus SSD for second-degree burns was studied. Materials and Methods: An open-label randomized controlled study was designed to compare the efficacy of using Suile^(TM) versus SSD (1% silver sulfadiazine, Smith & Nephew) as a second-degree burn topical treatment. Under IRB approval, 12 patients with second-degree burn wounds were recruited between 2010 and 2012 at the Linkou Burn Center (LBC) in Chang Gung Memorial Hospital, Taipei. All patients had two second-degree burn wounds of nearly the same size and depth as determined by two experienced burn doctors using clinical judgments such as positive blanching sign, etc. Patients requiring debridement or skin grafting were excluded. For a period of two weeks, patients received treatment using Suile^(TM) to one wound while SSD treatment was applied to the other wound. Wound status was documented with photography and Image J plus Area Calculator Plug-In. A paired t-test was used for statistical analysis. Results: A total of nine patients met the criteria for inclusion in the study. The patients had an average age of 40.33 years (range: 20-61 years). On the seventh day of treatment, the wound decreasing rate indicated that treatment using Suile^(TM) (average 14.1%) was slightly better than SSD (11.2%), although the p-value did not reach significance (p=0.123). Similar results were observed on the fourteenth day of treatment (Suile^(TM)=12.4% vs. SSD=10.5%, p=0.179). No adverse effects were found in either group. Conclusions: The current study population consisted of nine patients with second-degree burns, in which treatment using Suile^(TM) was not found to represent an improved alternative topical agent when compared with SSD treatment, despite a trend toward accelerated wound healing by the seventh day of treatment as monitored by clinical observation." @default.
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- W2298237029 date "2015-03-01" @default.
- W2298237029 modified "2023-09-24" @default.
- W2298237029 title "Bismuth Subgallate/Borneol (Suile^(TM)) Versus Silver Sulfadiazine for Second-degree Burn Wounds-A Randomized Controlled Study" @default.
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