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- W2298347813 abstract "Objective To observe the effect of ginkgo biloba extract (EGb)on the serum leptin, adiponectin, TNF-α and FFA concentration in insulin resistant rats induced by high fat diet.Methods Insulin resistant rats were induced by high fat diets firstly, and from the 4th week, the rats were intervened by EGb or rosiglitazone respectively.The intervention lasted for four weeks. Before and after the intervention, the hyperinsulinemic-euglycemic clamping was performed to determine the glucose infusion rate (GIR) and blood samples were taken to be detected fasting blood glucose, fasting insulin, free fatty acid, tumor necrosis factor-α, leptin and adiponectin.Results The insulin resistant model was successfully duplicated by high fat feeding. At the 4th week, the GIR decreased;and at the 8th week, the GIR decreased more significantly. There was statistical difference between the high fat feeding group and the normal control group (P<0.01). The high fat feeding group also showed high serum TNF-α and FFA, hypoadiponectinimia, the content of visceral fat tissue increased significantly. EGb not only increased GIR, but also decreased the level of serum TNF-α and FFA,increased the level of adiponectin,and the effect was similar with rosiglitazone. There was no difference in leptin level among these groups. The correlation analyze showed FFA was negatively correlated with GIR and the adiponectin was positively correlated with GIR.Conclusion EGb can modulate the secretion of adipocytokine, such as TNF-α, FFA and adiponectin. The modulation has correlation with the improved insulin sensitivity." @default.
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- W2298347813 date "2008-01-01" @default.
- W2298347813 modified "2023-09-27" @default.
- W2298347813 title "Effect of ginkgo biloba extract on serum leptin, adiponectin level in high fat diet induced insulin resistant model rats" @default.
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