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- W2298436567 abstract "Le développement de nouveaux antiviraux d’action directe a considérablement modifié les stratégies de prise en charge de l’hépatite C qui reposaient jusqu’en 2014 sur des associations à base d’interféron alpha. Notre objectif est d’analyser les résultats obtenus avec ces nouveaux médicaments et de discuter les schémas thérapeutiques disponibles dans la prise en charge de l’hépatite chronique C. Le traitement de référence de l’hépatite chronique C chez l’adulte repose désormais sur des associations d’antiviraux d’action directe avec ou sans ribavirine. Ces combinaisons permettent le plus souvent d’obtenir une guérison virologique (> 90 %, y compris chez les malades atteints de cirrhose non compliquée), grâce à un traitement de 12 semaines pour la majorité des patients, et d’élargir les indications thérapeutiques aux patients à plus haut besoin thérapeutique, notamment ceux inéligibles ou non répondeurs à l’interféron et/ou à la ribavirine. Dans certaines populations particulières (cirrhose compliquée, pré- ou post-transplantation, insuffisance rénale chronique, comorbidités…), les données sont encore limitées et des études complémentaires sont attendues pour valider les résultats disponibles. D’autres molécules sont également en cours de développement et devraient ouvrir de nouvelles perspectives thérapeutiques, notamment en termes de réduction de la durée de traitement ou de simplification thérapeutique. The development of new direct acting antivirals has significantly modified strategies to treat chronic hepatitis C. Treatments were previously made of an interferon-based combination. This article aims to review the direct acting antivirals clinical data and to discuss the new regimens for the management of chronic hepatitis C. Direct acting antivirals combinations – with or without ribavirin – are the new chronic hepatitis C standard treatment regimen. These combinations often result in sustained viral response rate (> 90%, including in patients with uncomplicated cirrhosis) after a 12-week treatment for most patients. The innovation could represent a new era for patients with unmet medical need (especially ineligible or non-responders to interferon and/or ribavirin patients). Further investigations are required to confirm the efficacy in specific population (complicated cirrhosis, pre- or post-transplantation, chronic renal failure, comorbidities, etc.) where clinical data are still limited. Other treatments are currently being developed and might lead to new perspectives, especially in terms of treatment duration or therapeutic simplification." @default.
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- W2298436567 date "2016-05-01" @default.
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- W2298436567 title "Infection par le virus de l’hépatite C : prise en charge thérapeutique" @default.
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- W2298436567 doi "https://doi.org/10.1016/j.lpm.2016.02.006" @default.
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