Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298497615> ?p ?o ?g. }
- W2298497615 endingPage "1778" @default.
- W2298497615 startingPage "1770" @default.
- W2298497615 abstract "Abstract The present study used a previously developed three‐dimensional Gelatin/Hydroxyapatite (Gel/HA) homogeneous nanocomposite scaffold with porosity of 82% and interconnecting pores ranging from 300 to 500 μm. Cell‐seeded scaffolds were used to evaluate bone regeneration of rat critical‐size calvarial defect. Totally, 36 male Wistar rats were randomly divided into four experimental groups, including blank defect (defects without any graft), blank scaffold (defects filled with Gel/HA scaffold without cells), and two groups of cell‐seeded scaffolds (defects filled with either Gel/HA scaffold seeded with osteoblast‐like and endothelial cells or osteoblast‐like cell‐seeded constructs). After 1, 4, and 12 weeks of scaffold implantation, rats were sacrificed and the calvaria were harvested for histological, immunohistochemical and histomorphometric analysis. In vitro tests showed that scaffolds were nontoxic to cells and promoted ideal cellular attachment. In vivo investigation on scaffold revealed that blank calvarial defects indicated incomplete tissue coverage and little evidence of bone healing. However, blank scaffold and cell‐seeded scaffolds significantly promoted osteoconduction and ostegogenesis. Taken together, pre‐seeded Gel/HA nanocomposite scaffold with osteoblasts and endothelial cells presented an effective combination to improve osteogenesis in the engineered bone implant. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1770–1778, 2016." @default.
- W2298497615 created "2016-06-24" @default.
- W2298497615 creator A5005063942 @default.
- W2298497615 creator A5005366049 @default.
- W2298497615 creator A5023978388 @default.
- W2298497615 creator A5033333376 @default.
- W2298497615 creator A5039508175 @default.
- W2298497615 creator A5048293762 @default.
- W2298497615 creator A5073273376 @default.
- W2298497615 creator A5074596754 @default.
- W2298497615 creator A5078273494 @default.
- W2298497615 date "2016-03-21" @default.
- W2298497615 modified "2023-10-08" @default.
- W2298497615 title "Repair of rat critical size calvarial defect using osteoblast-like and umbilical vein endothelial cells seeded in gelatin/hydroxyapatite scaffolds" @default.
- W2298497615 cites W194566379 @default.
- W2298497615 cites W1963984284 @default.
- W2298497615 cites W1966583669 @default.
- W2298497615 cites W1968694257 @default.
- W2298497615 cites W1969813590 @default.
- W2298497615 cites W1970224514 @default.
- W2298497615 cites W1972705632 @default.
- W2298497615 cites W1986335724 @default.
- W2298497615 cites W1986690707 @default.
- W2298497615 cites W1993836335 @default.
- W2298497615 cites W1999318759 @default.
- W2298497615 cites W2010061535 @default.
- W2298497615 cites W2012689543 @default.
- W2298497615 cites W2017109528 @default.
- W2298497615 cites W2020358908 @default.
- W2298497615 cites W2023063762 @default.
- W2298497615 cites W2023085572 @default.
- W2298497615 cites W2034402660 @default.
- W2298497615 cites W2034708479 @default.
- W2298497615 cites W204141082 @default.
- W2298497615 cites W2047470479 @default.
- W2298497615 cites W2050577276 @default.
- W2298497615 cites W2052953702 @default.
- W2298497615 cites W2054840381 @default.
- W2298497615 cites W2064781593 @default.
- W2298497615 cites W2064823562 @default.
- W2298497615 cites W2064882545 @default.
- W2298497615 cites W2066518402 @default.
- W2298497615 cites W2067833845 @default.
- W2298497615 cites W2068076106 @default.
- W2298497615 cites W2087285371 @default.
- W2298497615 cites W2088207317 @default.
- W2298497615 cites W2092367541 @default.
- W2298497615 cites W2096806264 @default.
- W2298497615 cites W2117374982 @default.
- W2298497615 cites W2117627538 @default.
- W2298497615 cites W2120791646 @default.
- W2298497615 cites W2132530742 @default.
- W2298497615 cites W2154072225 @default.
- W2298497615 cites W2158185401 @default.
- W2298497615 cites W2170816654 @default.
- W2298497615 doi "https://doi.org/10.1002/jbm.a.35710" @default.
- W2298497615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26990815" @default.
- W2298497615 hasPublicationYear "2016" @default.
- W2298497615 type Work @default.
- W2298497615 sameAs 2298497615 @default.
- W2298497615 citedByCount "39" @default.
- W2298497615 countsByYear W22984976152016 @default.
- W2298497615 countsByYear W22984976152017 @default.
- W2298497615 countsByYear W22984976152018 @default.
- W2298497615 countsByYear W22984976152019 @default.
- W2298497615 countsByYear W22984976152020 @default.
- W2298497615 countsByYear W22984976152021 @default.
- W2298497615 countsByYear W22984976152022 @default.
- W2298497615 countsByYear W22984976152023 @default.
- W2298497615 crossrefType "journal-article" @default.
- W2298497615 hasAuthorship W2298497615A5005063942 @default.
- W2298497615 hasAuthorship W2298497615A5005366049 @default.
- W2298497615 hasAuthorship W2298497615A5023978388 @default.
- W2298497615 hasAuthorship W2298497615A5033333376 @default.
- W2298497615 hasAuthorship W2298497615A5039508175 @default.
- W2298497615 hasAuthorship W2298497615A5048293762 @default.
- W2298497615 hasAuthorship W2298497615A5073273376 @default.
- W2298497615 hasAuthorship W2298497615A5074596754 @default.
- W2298497615 hasAuthorship W2298497615A5078273494 @default.
- W2298497615 hasConcept C136229726 @default.
- W2298497615 hasConcept C185592680 @default.
- W2298497615 hasConcept C192562407 @default.
- W2298497615 hasConcept C202751555 @default.
- W2298497615 hasConcept C2777411675 @default.
- W2298497615 hasConcept C2778260815 @default.
- W2298497615 hasConcept C2778823387 @default.
- W2298497615 hasConcept C2779918246 @default.
- W2298497615 hasConcept C49892992 @default.
- W2298497615 hasConcept C55493867 @default.
- W2298497615 hasConcept C71924100 @default.
- W2298497615 hasConcept C89429830 @default.
- W2298497615 hasConceptScore W2298497615C136229726 @default.
- W2298497615 hasConceptScore W2298497615C185592680 @default.
- W2298497615 hasConceptScore W2298497615C192562407 @default.
- W2298497615 hasConceptScore W2298497615C202751555 @default.
- W2298497615 hasConceptScore W2298497615C2777411675 @default.
- W2298497615 hasConceptScore W2298497615C2778260815 @default.
- W2298497615 hasConceptScore W2298497615C2778823387 @default.