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• W2298539891 endingPage "1011" @default.
• W2298539891 startingPage "994" @default.
• W2298539891 abstract "Gene duplication results in extra copies of genes that must coevolve with their interacting partners in multimeric protein complexes. The cardiac troponin (Tn) complex, containing TnC, TnI, and TnT, forms a distinct functional unit critical for the regulation of cardiac muscle contraction. In teleost fish, the function of the Tn complex is modified by the consequences of differential expression of paralogs in response to environmental thermal challenges. In this article, we focus on the interaction between TnI and TnC, coded for by genes that have independent evolutionary origins, but the co-operation of their protein products has necessitated coevolution. In this study, we characterize functional divergence of TnC and TnI paralogs, specifically the interrelated roles of regulatory subfunctionalization and structural subfunctionalization. We determined that differential paralog transcript expression in response to temperature acclimation results in three combinations of TnC and TnI in the zebrafish heart: TnC1a/TnI1.1, TnC1b/TnI1.1, and TnC1a/TnI1.5. Phylogenetic analysis of these highly conserved proteins identified functionally divergent residues in TnI and TnC. The structural and functional effect of these Tn combinations was modeled with molecular dynamics simulation to link divergent sites to changes in interaction strength. Functional divergence in TnI and TnC were not limited to the residues involved with TnC/TnI switch interaction, which emphasizes the complex nature of Tn function. Patterns in domain-specific divergent selection and interaction energies suggest that substitutions in the TnI switch region are crucial to modifying TnI/TnC function to maintain cardiac contraction with temperature changes. This integrative approach introduces Tn as a model of functional divergence that guides the coevolution of interacting proteins." @default.
• W2298539891 created "2016-06-24" @default.
• W2298539891 creator A5008515682 @default.
• W2298539891 creator A5017696854 @default.
• W2298539891 creator A5024951505 @default.
• W2298539891 creator A5028749728 @default.
• W2298539891 creator A5056202211 @default.
• W2298539891 creator A5061847009 @default.
• W2298539891 date "2016-03-15" @default.
• W2298539891 modified "2023-10-14" @default.
• W2298539891 title "Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC" @default.
• W2298539891 cites W12382117 @default.
• W2298539891 cites W1488871786 @default.
• W2298539891 cites W1499500424 @default.
• W2298539891 cites W1518270369 @default.
• W2298539891 cites W1546563018 @default.
• W2298539891 cites W1577577364 @default.
• W2298539891 cites W1785071502 @default.
• W2298539891 cites W1901823973 @default.
• W2298539891 cites W1913751214 @default.
• W2298539891 cites W1924552905 @default.
• W2298539891 cites W1964319581 @default.
• W2298539891 cites W1966990745 @default.
• W2298539891 cites W1967645030 @default.
• W2298539891 cites W1968371014 @default.
• W2298539891 cites W1969483763 @default.
• W2298539891 cites W1969944881 @default.
• W2298539891 cites W1973385358 @default.
• W2298539891 cites W1976499671 @default.
• W2298539891 cites W1985564400 @default.
• W2298539891 cites W1986191025 @default.
• W2298539891 cites W1996794667 @default.
• W2298539891 cites W1999722559 @default.
• W2298539891 cites W1999960938 @default.
• W2298539891 cites W2005637426 @default.
• W2298539891 cites W2009063516 @default.
• W2298539891 cites W2017519756 @default.
• W2298539891 cites W2026188828 @default.
• W2298539891 cites W2029158589 @default.
• W2298539891 cites W2029667189 @default.
• W2298539891 cites W2035266068 @default.
• W2298539891 cites W2035446727 @default.
• W2298539891 cites W2035733413 @default.
• W2298539891 cites W2038464976 @default.
• W2298539891 cites W2042312893 @default.
• W2298539891 cites W2043782165 @default.
• W2298539891 cites W2044172327 @default.
• W2298539891 cites W2044992198 @default.
• W2298539891 cites W2045910367 @default.
• W2298539891 cites W2053104183 @default.
• W2298539891 cites W2057477511 @default.
• W2298539891 cites W2058769300 @default.
• W2298539891 cites W2059194284 @default.
• W2298539891 cites W2064388657 @default.
• W2298539891 cites W2065921821 @default.
• W2298539891 cites W2070235328 @default.
• W2298539891 cites W2070946787 @default.
• W2298539891 cites W2074986801 @default.
• W2298539891 cites W2076234981 @default.
• W2298539891 cites W2088710031 @default.
• W2298539891 cites W2088933990 @default.
• W2298539891 cites W2089278448 @default.
• W2298539891 cites W2096163961 @default.
• W2298539891 cites W2097977090 @default.
• W2298539891 cites W2100640594 @default.
• W2298539891 cites W2101056276 @default.
• W2298539891 cites W2102793650 @default.
• W2298539891 cites W2105638686 @default.
• W2298539891 cites W2107580421 @default.
• W2298539891 cites W2110335151 @default.
• W2298539891 cites W2113880039 @default.
• W2298539891 cites W2114675905 @default.
• W2298539891 cites W2115148114 @default.
• W2298539891 cites W2116087481 @default.
• W2298539891 cites W2116829288 @default.
• W2298539891 cites W2116929704 @default.
• W2298539891 cites W2118839461 @default.
• W2298539891 cites W2119642862 @default.
• W2298539891 cites W2122337429 @default.
• W2298539891 cites W2125204768 @default.
• W2298539891 cites W2132432001 @default.
• W2298539891 cites W2132629607 @default.
• W2298539891 cites W2132632499 @default.
• W2298539891 cites W2132926880 @default.
• W2298539891 cites W2133585817 @default.
• W2298539891 cites W2137137210 @default.
• W2298539891 cites W2137845412 @default.
• W2298539891 cites W2142168944 @default.
• W2298539891 cites W2142705839 @default.
• W2298539891 cites W2144957001 @default.
• W2298539891 cites W2148058963 @default.
• W2298539891 cites W2152075687 @default.
• W2298539891 cites W2153110934 @default.
• W2298539891 cites W2154714625 @default.
• W2298539891 cites W2156340505 @default.
• W2298539891 cites W2157391111 @default.
• W2298539891 cites W2160344881 @default.
• W2298539891 cites W2160544821 @default.

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