Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298577667> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2298577667 endingPage "20" @default.
- W2298577667 startingPage "15" @default.
- W2298577667 abstract "Background: Portal endotoxemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation which is highly associated with the development of type 2 diabetes mellitus (T2DM). This study examined whether portal endotoxemia was a pathogenic link between chronic subacute hepatic inflammation and systemic insulin resistance. Methods: Rats were randomly assigned into four groups: rats with intraportal saline or with three different doses of lipopolysaccharide (LPS) infusion for 4 wks. Pathological changes in the liver were evaluated via histological and biochemical examination. Systemic insulin sensitivity was evaluated by euglycemic hyperinsulinemic clamp by the tracer dilution method. Results: Body weight, fasting whole blood glucose, plasma insulin, triglyceride levels, mean arterial blood pressure and heart rate were not significantly changed in the four-week infusion period for all groups. The biochemical indicators of hepatic function such as aspartate aminotransferase, alanine aminotransferase and albumin were not changed during the observed period for all groups. During the euglycemic hyperinsulinemic clamp period, the ratio of glucose infusion rate to insulin level, an index of whole body insulin sensitivity, did not change among groups. Accordingly, insulin-suppressed hepatic glucose production and insulin-stimulated whole body glucose utilization also failed to change in any of the groups at the end of the study. The histopatholgical examination revealed that intraportal low-dose LPS infusion progressively enhanced the inflammatory changes of the liver in experimental rats in a dose-dependent manner. Conclusion: The present study suggests that mild portal endotoxemia could induce chronic low-grade hepatic inflammation but does not significantly affect systemic insulin sensitivity in the present experimental condition." @default.
- W2298577667 created "2016-06-24" @default.
- W2298577667 creator A5014291268 @default.
- W2298577667 creator A5039117077 @default.
- W2298577667 creator A5045815530 @default.
- W2298577667 creator A5088203295 @default.
- W2298577667 date "2010-02-01" @default.
- W2298577667 modified "2023-09-27" @default.
- W2298577667 title "Chronic Hepatic Inflammation Induced by Mild Portal Endotoxemia is not Associated with Systemic Insulin Resistance in Rats" @default.
- W2298577667 doi "https://doi.org/10.6136/jms.2010.30(1).015" @default.
- W2298577667 hasPublicationYear "2010" @default.
- W2298577667 type Work @default.
- W2298577667 sameAs 2298577667 @default.
- W2298577667 citedByCount "0" @default.
- W2298577667 crossrefType "journal-article" @default.
- W2298577667 hasAuthorship W2298577667A5014291268 @default.
- W2298577667 hasAuthorship W2298577667A5039117077 @default.
- W2298577667 hasAuthorship W2298577667A5045815530 @default.
- W2298577667 hasAuthorship W2298577667A5088203295 @default.
- W2298577667 hasConcept C126322002 @default.
- W2298577667 hasConcept C134018914 @default.
- W2298577667 hasConcept C2776252253 @default.
- W2298577667 hasConcept C2776914184 @default.
- W2298577667 hasConcept C2777391703 @default.
- W2298577667 hasConcept C2779306644 @default.
- W2298577667 hasConcept C555293320 @default.
- W2298577667 hasConcept C71924100 @default.
- W2298577667 hasConceptScore W2298577667C126322002 @default.
- W2298577667 hasConceptScore W2298577667C134018914 @default.
- W2298577667 hasConceptScore W2298577667C2776252253 @default.
- W2298577667 hasConceptScore W2298577667C2776914184 @default.
- W2298577667 hasConceptScore W2298577667C2777391703 @default.
- W2298577667 hasConceptScore W2298577667C2779306644 @default.
- W2298577667 hasConceptScore W2298577667C555293320 @default.
- W2298577667 hasConceptScore W2298577667C71924100 @default.
- W2298577667 hasIssue "1" @default.
- W2298577667 hasLocation W22985776671 @default.
- W2298577667 hasOpenAccess W2298577667 @default.
- W2298577667 hasPrimaryLocation W22985776671 @default.
- W2298577667 hasRelatedWork W1516436527 @default.
- W2298577667 hasRelatedWork W1937800490 @default.
- W2298577667 hasRelatedWork W1977748501 @default.
- W2298577667 hasRelatedWork W2010458081 @default.
- W2298577667 hasRelatedWork W2015836575 @default.
- W2298577667 hasRelatedWork W2048135703 @default.
- W2298577667 hasRelatedWork W2066585001 @default.
- W2298577667 hasRelatedWork W2076784848 @default.
- W2298577667 hasRelatedWork W2125981511 @default.
- W2298577667 hasRelatedWork W2155676470 @default.
- W2298577667 hasRelatedWork W2349420002 @default.
- W2298577667 hasRelatedWork W2364734420 @default.
- W2298577667 hasRelatedWork W2460345017 @default.
- W2298577667 hasRelatedWork W2803455496 @default.
- W2298577667 hasRelatedWork W2897674868 @default.
- W2298577667 hasRelatedWork W2915471309 @default.
- W2298577667 hasRelatedWork W2942157927 @default.
- W2298577667 hasRelatedWork W2948118921 @default.
- W2298577667 hasRelatedWork W94346658 @default.
- W2298577667 hasRelatedWork W1860654061 @default.
- W2298577667 hasVolume "30" @default.
- W2298577667 isParatext "false" @default.
- W2298577667 isRetracted "false" @default.
- W2298577667 magId "2298577667" @default.
- W2298577667 workType "article" @default.