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- W2298607400 abstract "This research was developed and designed an orallydisintegrating mini-tablets (ODMTs) containing Metoclopramide HCl,using various pharmaceutical compositions to enhance patientcompliance. Metoclopramide HCl was formulated into orallydisintegrating mini-tablets using the direct compression method andsuitable excipients such as microcrystalline cellulose andTrehalose as the diluent, talc and magnesium stearate aslubricants. The excipients were mixed with Polyplasdone XL(crospovidone) and Primojel (sodium starch glycolate) atconcentration of 3%, 5% and 7 % w/w of each using a V-Shellblender. This was done in order to select and optimize theconcentration of the best superdisintegrants having the leastdisintegrating time and fastest dissolution. The flowability of thepowder mixtures were evaluated using Carr's index, angle of reposeand the Hausner ratio. The tablets were evaluated according to theUSP based on weight variation, thickness, hardness, friability,disintegration time, a simulated wetting test, and in-vitrodissolution. The determination of the most effective type andoptimal amount of superdisintegrants for orally disintegratingmini-tablets was manufactured by direct compression. The final dataof the study revealed that a combination of microcrystallinecellulose, Trehalose and 7% Polyplasdone XL produced the bestcombination after using the test previouslymentioned." @default.
- W2298607400 created "2016-06-24" @default.
- W2298607400 creator A5052864828 @default.
- W2298607400 date "2014-01-01" @default.
- W2298607400 modified "2023-09-23" @default.
- W2298607400 title "Development of an Orally Disintegrating Mini-Tablet (ODMTs) Containing Metoclopramide HCl to Enhance Patient Compliance" @default.
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