Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298632912> ?p ?o ?g. }
- W2298632912 endingPage "61" @default.
- W2298632912 startingPage "53" @default.
- W2298632912 abstract "The human papillomavirus type 16 E6 protein exerts a transforming activity through inactivation of tumor suppressor p53. Recently E6 has been shown to have additional transforming activities independent of p53. E6 is able to transactivate or repress several specific viral promoters. However, underlying molecular mechanisms and cellular target genes for the activity are not well understood. Using a differential hybridization technique, we identified the prothymosin α gene as a cellular target of E6 transactivation. E6 was able to transactivate the prothymosin α promoter in H358 cells lacking p53 and in C33A cells harboring a mutant p53 allele. Disruption of the E-box in intron 1 of the prothymosin α promoter abolished the responsiveness to E6. Then we determined if E6 up-regulates the expression of Myc, by which the prothymosin α promoter is transactivated through the E-box. We found that E6 is also able to transactivate the c- myc promoter in H358 cells and in C33A cells. These results suggest that E6 is able to transactivate the c- myc promoter independently of p53, and that the prothymosin α promoter is subsequently transactivated by Myc." @default.
- W2298632912 created "2016-06-24" @default.
- W2298632912 creator A5019832552 @default.
- W2298632912 creator A5024193902 @default.
- W2298632912 creator A5039788222 @default.
- W2298632912 creator A5043955969 @default.
- W2298632912 creator A5065472017 @default.
- W2298632912 creator A5074881295 @default.
- W2298632912 creator A5088886028 @default.
- W2298632912 date "1997-05-01" @default.
- W2298632912 modified "2023-10-18" @default.
- W2298632912 title "Transactivation of Prothymosin α and c-mycPromoters by Human Papillomavirus Type 16 E6 Protein" @default.
- W2298632912 cites W128302075 @default.
- W2298632912 cites W1491764330 @default.
- W2298632912 cites W1493793804 @default.
- W2298632912 cites W1516627538 @default.
- W2298632912 cites W1525939857 @default.
- W2298632912 cites W1544092207 @default.
- W2298632912 cites W1559244741 @default.
- W2298632912 cites W1576196054 @default.
- W2298632912 cites W1595608936 @default.
- W2298632912 cites W1620032110 @default.
- W2298632912 cites W1660660796 @default.
- W2298632912 cites W1675635349 @default.
- W2298632912 cites W168561149 @default.
- W2298632912 cites W174785446 @default.
- W2298632912 cites W1761926992 @default.
- W2298632912 cites W1782055207 @default.
- W2298632912 cites W1969881374 @default.
- W2298632912 cites W1977344910 @default.
- W2298632912 cites W1986169988 @default.
- W2298632912 cites W1988476984 @default.
- W2298632912 cites W2002550426 @default.
- W2298632912 cites W2008415422 @default.
- W2298632912 cites W2012094473 @default.
- W2298632912 cites W2015519364 @default.
- W2298632912 cites W2017108484 @default.
- W2298632912 cites W2026382817 @default.
- W2298632912 cites W2029735450 @default.
- W2298632912 cites W2033800738 @default.
- W2298632912 cites W2038500217 @default.
- W2298632912 cites W2039382131 @default.
- W2298632912 cites W2060786724 @default.
- W2298632912 cites W2063158632 @default.
- W2298632912 cites W2069203540 @default.
- W2298632912 cites W2074222004 @default.
- W2298632912 cites W2076059928 @default.
- W2298632912 cites W2078341711 @default.
- W2298632912 cites W2080766591 @default.
- W2298632912 cites W2089218510 @default.
- W2298632912 cites W2106038494 @default.
- W2298632912 cites W2116529873 @default.
- W2298632912 cites W2124166821 @default.
- W2298632912 cites W2138674891 @default.
- W2298632912 cites W2146076281 @default.
- W2298632912 cites W2146581496 @default.
- W2298632912 cites W2152688096 @default.
- W2298632912 cites W2170939558 @default.
- W2298632912 cites W2173601290 @default.
- W2298632912 cites W2289751621 @default.
- W2298632912 cites W38542220 @default.
- W2298632912 cites W1974894607 @default.
- W2298632912 cites W2082325990 @default.
- W2298632912 doi "https://doi.org/10.1006/viro.1997.8536" @default.
- W2298632912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9185588" @default.
- W2298632912 hasPublicationYear "1997" @default.
- W2298632912 type Work @default.
- W2298632912 sameAs 2298632912 @default.
- W2298632912 citedByCount "46" @default.
- W2298632912 countsByYear W22986329122012 @default.
- W2298632912 countsByYear W22986329122018 @default.
- W2298632912 countsByYear W22986329122019 @default.
- W2298632912 countsByYear W22986329122020 @default.
- W2298632912 countsByYear W22986329122021 @default.
- W2298632912 countsByYear W22986329122022 @default.
- W2298632912 crossrefType "journal-article" @default.
- W2298632912 hasAuthorship W2298632912A5019832552 @default.
- W2298632912 hasAuthorship W2298632912A5024193902 @default.
- W2298632912 hasAuthorship W2298632912A5039788222 @default.
- W2298632912 hasAuthorship W2298632912A5043955969 @default.
- W2298632912 hasAuthorship W2298632912A5065472017 @default.
- W2298632912 hasAuthorship W2298632912A5074881295 @default.
- W2298632912 hasAuthorship W2298632912A5088886028 @default.
- W2298632912 hasBestOaLocation W22986329121 @default.
- W2298632912 hasConcept C101762097 @default.
- W2298632912 hasConcept C104317684 @default.
- W2298632912 hasConcept C1292079 @default.
- W2298632912 hasConcept C150194340 @default.
- W2298632912 hasConcept C153911025 @default.
- W2298632912 hasConcept C158448853 @default.
- W2298632912 hasConcept C179185449 @default.
- W2298632912 hasConcept C502942594 @default.
- W2298632912 hasConcept C55493867 @default.
- W2298632912 hasConcept C86339819 @default.
- W2298632912 hasConcept C86803240 @default.
- W2298632912 hasConcept C95444343 @default.
- W2298632912 hasConceptScore W2298632912C101762097 @default.
- W2298632912 hasConceptScore W2298632912C104317684 @default.