FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298669488> ?p ?o ?g. }

• W2298669488 endingPage "3349" @default.
• W2298669488 startingPage "3336" @default.
• W2298669488 abstract "Neurons that signal the orientation of edges within the visual field have been widely studied in primary visual cortex. Much less is known about the mechanisms of orientation selectivity that arise earlier in the visual stream. Here we examine the synaptic and morphological properties of a subtype of orientation-selective ganglion cell in the rabbit retina. The receptive field has an excitatory ON center, flanked by excitatory OFF regions, a structure similar to simple cell receptive fields in primary visual cortex. Examination of the light-evoked postsynaptic currents in these ON-type orientation-selective ganglion cells (ON-OSGCs) reveals that synaptic input is mediated almost exclusively through the ON pathway. Orientation selectivity is generated by larger excitation for preferred relative to orthogonal stimuli, and conversely larger inhibition for orthogonal relative to preferred stimuli. Excitatory orientation selectivity arises in part from the morphology of the dendritic arbors. Blocking GABA A receptors reduces orientation selectivity of the inhibitory synaptic inputs and the spiking responses. Negative contrast stimuli in the flanking regions produce orientation-selective excitation in part by disinhibition of a tonic NMDA receptor-mediated input arising from ON bipolar cells. Comparison with earlier studies of OFF-type OSGCs indicates that diverse synaptic circuits have evolved in the retina to detect the orientation of edges in the visual input. SIGNIFICANCE STATEMENT A core goal for visual neuroscientists is to understand how neural circuits at each stage of the visual system extract and encode features from the visual scene. This study documents a novel type of orientation-selective ganglion cell in the retina and shows that the receptive field structure is remarkably similar to that of simple cells in primary visual cortex. However, the data indicate that, unlike in the cortex, orientation selectivity in the retina depends on the activity of inhibitory interneurons. The results further reveal the physiological basis for feature detection in the visual system, elucidate the synaptic mechanisms that generate orientation selectivity at an early stage of visual processing, and illustrate a novel role for NMDA receptors in retinal processing." @default.
• W2298669488 created "2016-06-24" @default.
• W2298669488 creator A5051705937 @default.
• W2298669488 creator A5064811395 @default.
• W2298669488 date "2016-03-16" @default.
• W2298669488 modified "2023-10-16" @default.
• W2298669488 title "Synaptic Mechanisms Generating Orientation Selectivity in the ON Pathway of the Rabbit Retina" @default.
• W2298669488 cites W1491463220 @default.
• W2298669488 cites W1522488279 @default.
• W2298669488 cites W1576689446 @default.
• W2298669488 cites W1612799171 @default.
• W2298669488 cites W1939828159 @default.
• W2298669488 cites W1964180894 @default.
• W2298669488 cites W1970030146 @default.
• W2298669488 cites W1971984616 @default.
• W2298669488 cites W1980641455 @default.
• W2298669488 cites W1984207986 @default.
• W2298669488 cites W1994715314 @default.
• W2298669488 cites W1994868555 @default.
• W2298669488 cites W1999499253 @default.
• W2298669488 cites W1999612489 @default.
• W2298669488 cites W2000364054 @default.
• W2298669488 cites W2000688860 @default.
• W2298669488 cites W2009452186 @default.
• W2298669488 cites W2018733287 @default.
• W2298669488 cites W2019990453 @default.
• W2298669488 cites W2021608851 @default.
• W2298669488 cites W2026960446 @default.
• W2298669488 cites W2028805622 @default.
• W2298669488 cites W2032404210 @default.
• W2298669488 cites W2034722615 @default.
• W2298669488 cites W2037852973 @default.
• W2298669488 cites W2043261639 @default.
• W2298669488 cites W2046297486 @default.
• W2298669488 cites W2046504812 @default.
• W2298669488 cites W2058483899 @default.
• W2298669488 cites W2059058130 @default.
• W2298669488 cites W2063386691 @default.
• W2298669488 cites W2064094924 @default.
• W2298669488 cites W2064449994 @default.
• W2298669488 cites W2069317420 @default.
• W2298669488 cites W2072521404 @default.
• W2298669488 cites W2072891349 @default.
• W2298669488 cites W2075877638 @default.
• W2298669488 cites W2076321475 @default.
• W2298669488 cites W2077105925 @default.
• W2298669488 cites W2078951688 @default.
• W2298669488 cites W2087843537 @default.
• W2298669488 cites W2089708590 @default.
• W2298669488 cites W2090476414 @default.
• W2298669488 cites W2090923339 @default.
• W2298669488 cites W2091421470 @default.
• W2298669488 cites W2093860743 @default.
• W2298669488 cites W2099540110 @default.
• W2298669488 cites W2099616257 @default.
• W2298669488 cites W2100698933 @default.
• W2298669488 cites W2109596819 @default.
• W2298669488 cites W2113176895 @default.
• W2298669488 cites W2115135943 @default.
• W2298669488 cites W2116360511 @default.
• W2298669488 cites W2118652880 @default.
• W2298669488 cites W2121289914 @default.
• W2298669488 cites W2124934034 @default.
• W2298669488 cites W2125277430 @default.
• W2298669488 cites W2126020484 @default.
• W2298669488 cites W2130127881 @default.
• W2298669488 cites W2132242046 @default.
• W2298669488 cites W2139286763 @default.
• W2298669488 cites W2147501287 @default.
• W2298669488 cites W2149672539 @default.
• W2298669488 cites W2150614550 @default.
• W2298669488 cites W2151035455 @default.
• W2298669488 cites W2153173219 @default.
• W2298669488 cites W2164792033 @default.
• W2298669488 cites W2166931327 @default.
• W2298669488 cites W2313348546 @default.
• W2298669488 cites W2465959243 @default.
• W2298669488 doi "https://doi.org/10.1523/jneurosci.1432-15.2016" @default.
• W2298669488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4792943" @default.
• W2298669488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26985041" @default.
• W2298669488 hasPublicationYear "2016" @default.
• W2298669488 type Work @default.
• W2298669488 sameAs 2298669488 @default.
• W2298669488 citedByCount "20" @default.
• W2298669488 countsByYear W22986694882016 @default.
• W2298669488 countsByYear W22986694882017 @default.
• W2298669488 countsByYear W22986694882018 @default.
• W2298669488 countsByYear W22986694882019 @default.
• W2298669488 countsByYear W22986694882020 @default.
• W2298669488 countsByYear W22986694882021 @default.
• W2298669488 countsByYear W22986694882022 @default.
• W2298669488 countsByYear W22986694882023 @default.
• W2298669488 crossrefType "journal-article" @default.
• W2298669488 hasAuthorship W2298669488A5051705937 @default.
• W2298669488 hasAuthorship W2298669488A5064811395 @default.
• W2298669488 hasBestOaLocation W22986694881 @default.
• W2298669488 hasConcept C112592302 @default.
• W2298669488 hasConcept C119088629 @default.

• next