FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298678407> ?p ?o ?g. }

• W2298678407 abstract "Acacia hydaspica R. Parker is known for its medicinal uses in multiple ailments. In this study, we performed bioassay-guided fractionation of cytotoxic compounds from A. hydaspica and investigated their effects on growth and signaling activity in prostate and breast cancer cell lines. Four active polyphenolic compounds were identified as 7-O-galloyl catechin (GC), catechin (C), methyl gallate (MG), and catechin-3-O-gallate (CG). The four compounds inhibited prostate cancer PC-3 cell growth in a dose-dependent manner, whereas CG and MG inhibited breast cancer MDA-MB-231 cell growth. All tested compounds inhibited cell survival and colony growth in both cell lines, and there was evidence of chromatin condensation, cell shrinkage and apoptotic bodies. Further, acridine orange, ethidium bromide, propidium iodide and DAPI staining demonstrated that cell death occurred partly via apoptosis in both PC-3 and MDA-MB-231 cells. In PC-3 cells treatment repressed the expression of anti-apoptotic molecules Bcl-2, Bcl-xL and survivin, coupled with down-regulation of signaling pathways AKT, NFκB, ERK1/2 and JAK/STAT. In MDA-MB-231 cells, treatment induced reduction of CK2α, Bcl-xL, survivin and xIAP protein expression along with suppression of NFκB, JAK/STAT and PI3K pathways. Our findings suggest that certain polyphenolic compounds derived from A. hydaspica may be promising chemopreventive/therapeutic candidates against cancer." @default.
• W2298678407 created "2016-06-24" @default.
• W2298678407 creator A5005593638 @default.
• W2298678407 creator A5026355032 @default.
• W2298678407 creator A5032908029 @default.
• W2298678407 creator A5047745567 @default.
• W2298678407 creator A5078268367 @default.
• W2298678407 creator A5079551997 @default.
• W2298678407 date "2016-03-15" @default.
• W2298678407 modified "2023-10-09" @default.
• W2298678407 title "Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways" @default.
• W2298678407 cites W1176146861 @default.
• W2298678407 cites W1694093395 @default.
• W2298678407 cites W1961997323 @default.
• W2298678407 cites W1972056075 @default.
• W2298678407 cites W1982286655 @default.
• W2298678407 cites W1985753549 @default.
• W2298678407 cites W1989428273 @default.
• W2298678407 cites W1996165605 @default.
• W2298678407 cites W1999375857 @default.
• W2298678407 cites W2002801265 @default.
• W2298678407 cites W2012137238 @default.
• W2298678407 cites W2020861824 @default.
• W2298678407 cites W2022709609 @default.
• W2298678407 cites W2025312106 @default.
• W2298678407 cites W2030904288 @default.
• W2298678407 cites W2043118554 @default.
• W2298678407 cites W2056907126 @default.
• W2298678407 cites W2057296956 @default.
• W2298678407 cites W2063146856 @default.
• W2298678407 cites W2066700651 @default.
• W2298678407 cites W2070330288 @default.
• W2298678407 cites W2071630377 @default.
• W2298678407 cites W2075033480 @default.
• W2298678407 cites W2075211183 @default.
• W2298678407 cites W2078374613 @default.
• W2298678407 cites W2087027618 @default.
• W2298678407 cites W2090898691 @default.
• W2298678407 cites W2104377312 @default.
• W2298678407 cites W2113057298 @default.
• W2298678407 cites W2131198704 @default.
• W2298678407 cites W2133540186 @default.
• W2298678407 cites W2134539328 @default.
• W2298678407 cites W2135642745 @default.
• W2298678407 cites W2140552371 @default.
• W2298678407 cites W2141736687 @default.
• W2298678407 cites W2148287035 @default.
• W2298678407 cites W2152635758 @default.
• W2298678407 cites W2155290347 @default.
• W2298678407 cites W2158944838 @default.
• W2298678407 cites W2163895012 @default.
• W2298678407 cites W2170552969 @default.
• W2298678407 doi "https://doi.org/10.1038/srep23077" @default.
• W2298678407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791679" @default.
• W2298678407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26975752" @default.
• W2298678407 hasPublicationYear "2016" @default.
• W2298678407 type Work @default.
• W2298678407 sameAs 2298678407 @default.
• W2298678407 citedByCount "85" @default.
• W2298678407 countsByYear W22986784072016 @default.
• W2298678407 countsByYear W22986784072017 @default.
• W2298678407 countsByYear W22986784072018 @default.
• W2298678407 countsByYear W22986784072019 @default.
• W2298678407 countsByYear W22986784072020 @default.
• W2298678407 countsByYear W22986784072021 @default.
• W2298678407 countsByYear W22986784072022 @default.
• W2298678407 countsByYear W22986784072023 @default.
• W2298678407 crossrefType "journal-article" @default.
• W2298678407 hasAuthorship W2298678407A5005593638 @default.
• W2298678407 hasAuthorship W2298678407A5026355032 @default.
• W2298678407 hasAuthorship W2298678407A5032908029 @default.
• W2298678407 hasAuthorship W2298678407A5047745567 @default.
• W2298678407 hasAuthorship W2298678407A5078268367 @default.
• W2298678407 hasAuthorship W2298678407A5079551997 @default.
• W2298678407 hasBestOaLocation W22986784071 @default.
• W2298678407 hasConcept C121608353 @default.
• W2298678407 hasConcept C185592680 @default.
• W2298678407 hasConcept C190283241 @default.
• W2298678407 hasConcept C2775934118 @default.
• W2298678407 hasConcept C2775975398 @default.
• W2298678407 hasConcept C2779102032 @default.
• W2298678407 hasConcept C31573885 @default.
• W2298678407 hasConcept C33195913 @default.
• W2298678407 hasConcept C502942594 @default.
• W2298678407 hasConcept C54355233 @default.
• W2298678407 hasConcept C55493867 @default.
• W2298678407 hasConcept C62112901 @default.
• W2298678407 hasConcept C62478195 @default.
• W2298678407 hasConcept C75217442 @default.
• W2298678407 hasConcept C86803240 @default.
• W2298678407 hasConcept C96232424 @default.
• W2298678407 hasConcept C98424977 @default.
• W2298678407 hasConceptScore W2298678407C121608353 @default.
• W2298678407 hasConceptScore W2298678407C185592680 @default.
• W2298678407 hasConceptScore W2298678407C190283241 @default.
• W2298678407 hasConceptScore W2298678407C2775934118 @default.
• W2298678407 hasConceptScore W2298678407C2775975398 @default.
• W2298678407 hasConceptScore W2298678407C2779102032 @default.
• W2298678407 hasConceptScore W2298678407C31573885 @default.
• W2298678407 hasConceptScore W2298678407C33195913 @default.

• next