Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298782308> ?p ?o ?g. }
- W2298782308 abstract "Abstract Post-learning hippocampal sharp wave-ripples (SWRs) generated during slow wave sleep are thought to play a crucial role in memory formation. While in Alzheimer’s disease, abnormal hippocampal oscillations have been reported, the functional contribution of SWRs to the typically observed spatial memory impairments remains unclear. These impairments have been related to degenerative synaptic changes produced by soluble amyloid beta oligomers (Aβos) which, surprisingly, seem to spare the SWR dynamics during routine behavior. To unravel a potential effect of Aβos on SWRs in cognitively-challenged animals, we submitted vehicle- and Aβo-injected mice to spatial recognition memory testing. While capable of forming short-term recognition memory, Aβ mice exhibited faster forgetting, suggesting successful encoding but an inability to adequately stabilize and/or retrieve previously acquired information. Without prior cognitive requirements, similar properties of SWRs were observed in both groups. In contrast, when cognitively challenged, the post-encoding and -recognition peaks in SWR occurrence observed in controls were abolished in Aβ mice, indicating impaired hippocampal processing of spatial information. These results point to a crucial involvement of SWRs in spatial memory formation and identify the Aβ-induced impairment in SWRs dynamics as a disruptive mechanism responsible for the spatial memory deficits associated with Alzheimer’s disease." @default.
- W2298782308 created "2016-06-24" @default.
- W2298782308 creator A5035223345 @default.
- W2298782308 creator A5046009514 @default.
- W2298782308 creator A5070388191 @default.
- W2298782308 creator A5075087379 @default.
- W2298782308 creator A5087279953 @default.
- W2298782308 creator A5088446845 @default.
- W2298782308 date "2016-03-07" @default.
- W2298782308 modified "2023-10-13" @default.
- W2298782308 title "Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation" @default.
- W2298782308 cites W1550995133 @default.
- W2298782308 cites W1580041071 @default.
- W2298782308 cites W1584834830 @default.
- W2298782308 cites W1967456522 @default.
- W2298782308 cites W1985582399 @default.
- W2298782308 cites W1987834694 @default.
- W2298782308 cites W1988697672 @default.
- W2298782308 cites W2002280328 @default.
- W2298782308 cites W2004222132 @default.
- W2298782308 cites W2008915709 @default.
- W2298782308 cites W2017816448 @default.
- W2298782308 cites W2024758252 @default.
- W2298782308 cites W2034208007 @default.
- W2298782308 cites W2034641170 @default.
- W2298782308 cites W2037321375 @default.
- W2298782308 cites W2042909958 @default.
- W2298782308 cites W2046262142 @default.
- W2298782308 cites W2062205907 @default.
- W2298782308 cites W2063236931 @default.
- W2298782308 cites W2069750066 @default.
- W2298782308 cites W2080225612 @default.
- W2298782308 cites W2080638151 @default.
- W2298782308 cites W2082429191 @default.
- W2298782308 cites W2087607255 @default.
- W2298782308 cites W2106931873 @default.
- W2298782308 cites W2110073081 @default.
- W2298782308 cites W2118168358 @default.
- W2298782308 cites W2126402425 @default.
- W2298782308 cites W2133631618 @default.
- W2298782308 cites W2143853187 @default.
- W2298782308 cites W2167793692 @default.
- W2298782308 cites W2168172321 @default.
- W2298782308 cites W4214953342 @default.
- W2298782308 doi "https://doi.org/10.1038/srep22728" @default.
- W2298782308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4779992" @default.
- W2298782308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26947247" @default.
- W2298782308 hasPublicationYear "2016" @default.
- W2298782308 type Work @default.
- W2298782308 sameAs 2298782308 @default.
- W2298782308 citedByCount "39" @default.
- W2298782308 countsByYear W22987823082016 @default.
- W2298782308 countsByYear W22987823082017 @default.
- W2298782308 countsByYear W22987823082018 @default.
- W2298782308 countsByYear W22987823082019 @default.
- W2298782308 countsByYear W22987823082020 @default.
- W2298782308 countsByYear W22987823082021 @default.
- W2298782308 countsByYear W22987823082022 @default.
- W2298782308 countsByYear W22987823082023 @default.
- W2298782308 crossrefType "journal-article" @default.
- W2298782308 hasAuthorship W2298782308A5035223345 @default.
- W2298782308 hasAuthorship W2298782308A5046009514 @default.
- W2298782308 hasAuthorship W2298782308A5070388191 @default.
- W2298782308 hasAuthorship W2298782308A5075087379 @default.
- W2298782308 hasAuthorship W2298782308A5087279953 @default.
- W2298782308 hasAuthorship W2298782308A5088446845 @default.
- W2298782308 hasBestOaLocation W22987823081 @default.
- W2298782308 hasConcept C125411270 @default.
- W2298782308 hasConcept C126322002 @default.
- W2298782308 hasConcept C148762608 @default.
- W2298782308 hasConcept C15744967 @default.
- W2298782308 hasConcept C169760540 @default.
- W2298782308 hasConcept C169900460 @default.
- W2298782308 hasConcept C180747234 @default.
- W2298782308 hasConcept C2776156579 @default.
- W2298782308 hasConcept C2778615406 @default.
- W2298782308 hasConcept C2779134260 @default.
- W2298782308 hasConcept C2781161787 @default.
- W2298782308 hasConcept C2993691153 @default.
- W2298782308 hasConcept C3018842126 @default.
- W2298782308 hasConcept C7149132 @default.
- W2298782308 hasConcept C71924100 @default.
- W2298782308 hasConceptScore W2298782308C125411270 @default.
- W2298782308 hasConceptScore W2298782308C126322002 @default.
- W2298782308 hasConceptScore W2298782308C148762608 @default.
- W2298782308 hasConceptScore W2298782308C15744967 @default.
- W2298782308 hasConceptScore W2298782308C169760540 @default.
- W2298782308 hasConceptScore W2298782308C169900460 @default.
- W2298782308 hasConceptScore W2298782308C180747234 @default.
- W2298782308 hasConceptScore W2298782308C2776156579 @default.
- W2298782308 hasConceptScore W2298782308C2778615406 @default.
- W2298782308 hasConceptScore W2298782308C2779134260 @default.
- W2298782308 hasConceptScore W2298782308C2781161787 @default.
- W2298782308 hasConceptScore W2298782308C2993691153 @default.
- W2298782308 hasConceptScore W2298782308C3018842126 @default.
- W2298782308 hasConceptScore W2298782308C7149132 @default.
- W2298782308 hasConceptScore W2298782308C71924100 @default.
- W2298782308 hasIssue "1" @default.
- W2298782308 hasLocation W22987823081 @default.
- W2298782308 hasLocation W22987823082 @default.