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- W2298790121 abstract "Objectives. Adjuvant and neoadjuvant chemotherapy is increasingly being used in the treatment of breast cancer patients. Determining the mechanisms of drug resistance is imperative for the development of rational therapeutic strategies. The expression of Ki-67, P-glycoprotein (Pgp), or mutant p53 (p53) involves the resistance to cytotoxic drugs. Only one preliminary study has tried the clinical use of thallium-201 (201Tl) mammoscintigraphy for noninvasive and in vivo determination of Ki-67 expression. However, no association of 201Tl mammoscintigraphic findings and Pgp or p53 in human breast cancers was studied. Therefore, the aim of this study was to compare 201Tl mammoscintigraphic findings with the expression of Ki-67, Pgp, and p53 in human breast cancers.Methods. Twenty-four patients diagnosed with infiltrating ductal breast cancer underwent mammoscintigraphy with thallium-201 (201Tl) single photon emission computed tomography (SPECT) before surgery or biopsy. Protein expression was investigated by immunohistochemical analyses on multiple nonconsecutive sections from surgery or biopsy specimens. Tumor to background (T/B) ratios calculated by 201Tl SPECT mammoscintigraphic findings were correlated with protein expression determined by immunohistochemical analyses.Results. The T/B ratios were significantly higher for tumors in 11 patients with positive Ki-67 expression than for those in 13 patients with negative expression (4.26 ± 0.41 and 2.25 ± 0.33, p ＜ 0.05). However, differences in T/B ratios between the patients with positive and negative Pgp or p53 expression were not found in this study.Conclusions. Our data confirmed that T/B ratios calculated from 201Tl SPECT mammoscintigrapy are useful for determination of the presence of Ki-67 expression in breast cancers, but no significant relations between T/B ratios and Pgp or p53 were found." @default.
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- W2298790121 date "2003-12-01" @default.
- W2298790121 modified "2023-10-17" @default.
- W2298790121 title "Correlation of Thallium-201 Mammoscintigraphic Results with P-Glycoprotein, Ki-67, and P53 Expression in Breast Cancers" @default.
- W2298790121 doi "https://doi.org/10.6558/mtjm.2003.8(c).9" @default.
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