FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298796614> ?p ?o ?g. }

• W2298796614 endingPage "5888" @default.
• W2298796614 startingPage "5879" @default.
• W2298796614 abstract "Mcm10 is required for the initiation of eukaryotic DNA replication and contributes in some unknown way to the activation of the Cdc45-MCM-GINS (CMG) helicase. How Mcm10 is localized to sites of replication initiation is unclear, as current models indicate that direct binding to minichromosome maintenance (MCM) plays a role, but the details and functional importance of this interaction have not been determined. Here, we show that purified Mcm10 can bind both DNA-bound double hexamers and soluble single hexamers of MCM. The binding of Mcm10 to MCM requires the Mcm10 C terminus. Moreover, the binding site for Mcm10 on MCM includes the Mcm2 and Mcm6 subunits and overlaps that for the loading factor Cdt1. Whether Mcm10 recruitment to replication origins depends on CMG helicase assembly has been unclear. We show that Mcm10 recruitment occurs via two modes: low affinity recruitment in the absence of CMG assembly (G1-like) and high affinity recruitment when CMG assembly takes place (S-phase-like). Mcm10 that cannot bind directly to MCM is defective in both modes of recruitment and is unable to support DNA replication. These findings indicate that Mcm10 is localized to replication initiation sites by directly binding MCM through the Mcm10 C terminus." @default.
• W2298796614 created "2016-06-24" @default.
• W2298796614 creator A5029333589 @default.
• W2298796614 creator A5075638597 @default.
• W2298796614 date "2016-03-01" @default.
• W2298796614 modified "2023-10-12" @default.
• W2298796614 title "Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex" @default.
• W2298796614 cites W1136494239 @default.
• W2298796614 cites W1866059572 @default.
• W2298796614 cites W1967998674 @default.
• W2298796614 cites W1995958788 @default.
• W2298796614 cites W1997289911 @default.
• W2298796614 cites W2005324074 @default.
• W2298796614 cites W2005856077 @default.
• W2298796614 cites W2007214324 @default.
• W2298796614 cites W2013346022 @default.
• W2298796614 cites W2025125294 @default.
• W2298796614 cites W2038427905 @default.
• W2298796614 cites W2044440192 @default.
• W2298796614 cites W2063733249 @default.
• W2298796614 cites W2065971145 @default.
• W2298796614 cites W2066983187 @default.
• W2298796614 cites W2071019833 @default.
• W2298796614 cites W2074844995 @default.
• W2298796614 cites W2085365618 @default.
• W2298796614 cites W2099487576 @default.
• W2298796614 cites W2105092225 @default.
• W2298796614 cites W2105413529 @default.
• W2298796614 cites W2111275137 @default.
• W2298796614 cites W2126909443 @default.
• W2298796614 cites W2127043939 @default.
• W2298796614 cites W2130115977 @default.
• W2298796614 cites W2130717106 @default.
• W2298796614 cites W2137724028 @default.
• W2298796614 cites W2138001436 @default.
• W2298796614 cites W2150000259 @default.
• W2298796614 cites W2154046032 @default.
• W2298796614 cites W2165749026 @default.
• W2298796614 cites W2165914686 @default.
• W2298796614 cites W3198823065 @default.
• W2298796614 doi "https://doi.org/10.1074/jbc.m115.707802" @default.
• W2298796614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4786722" @default.
• W2298796614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26719337" @default.
• W2298796614 hasPublicationYear "2016" @default.
• W2298796614 type Work @default.
• W2298796614 sameAs 2298796614 @default.
• W2298796614 citedByCount "44" @default.
• W2298796614 countsByYear W22987966142016 @default.
• W2298796614 countsByYear W22987966142017 @default.
• W2298796614 countsByYear W22987966142018 @default.
• W2298796614 countsByYear W22987966142019 @default.
• W2298796614 countsByYear W22987966142020 @default.
• W2298796614 countsByYear W22987966142021 @default.
• W2298796614 countsByYear W22987966142022 @default.
• W2298796614 countsByYear W22987966142023 @default.
• W2298796614 crossrefType "journal-article" @default.
• W2298796614 hasAuthorship W2298796614A5029333589 @default.
• W2298796614 hasAuthorship W2298796614A5075638597 @default.
• W2298796614 hasBestOaLocation W22987966141 @default.
• W2298796614 hasConcept C12590798 @default.
• W2298796614 hasConcept C151158763 @default.
• W2298796614 hasConcept C159047783 @default.
• W2298796614 hasConcept C175248279 @default.
• W2298796614 hasConcept C2780091387 @default.
• W2298796614 hasConcept C54355233 @default.
• W2298796614 hasConcept C552990157 @default.
• W2298796614 hasConcept C73573662 @default.
• W2298796614 hasConcept C83640560 @default.
• W2298796614 hasConcept C86803240 @default.
• W2298796614 hasConcept C95444343 @default.
• W2298796614 hasConcept C98086919 @default.
• W2298796614 hasConceptScore W2298796614C12590798 @default.
• W2298796614 hasConceptScore W2298796614C151158763 @default.
• W2298796614 hasConceptScore W2298796614C159047783 @default.
• W2298796614 hasConceptScore W2298796614C175248279 @default.
• W2298796614 hasConceptScore W2298796614C2780091387 @default.
• W2298796614 hasConceptScore W2298796614C54355233 @default.
• W2298796614 hasConceptScore W2298796614C552990157 @default.
• W2298796614 hasConceptScore W2298796614C73573662 @default.
• W2298796614 hasConceptScore W2298796614C83640560 @default.
• W2298796614 hasConceptScore W2298796614C86803240 @default.
• W2298796614 hasConceptScore W2298796614C95444343 @default.
• W2298796614 hasConceptScore W2298796614C98086919 @default.
• W2298796614 hasFunder F4320307874 @default.
• W2298796614 hasIssue "11" @default.
• W2298796614 hasLocation W22987966141 @default.
• W2298796614 hasLocation W22987966142 @default.
• W2298796614 hasLocation W22987966143 @default.
• W2298796614 hasLocation W22987966144 @default.
• W2298796614 hasOpenAccess W2298796614 @default.
• W2298796614 hasPrimaryLocation W22987966141 @default.
• W2298796614 hasRelatedWork W1517584908 @default.
• W2298796614 hasRelatedWork W1780211834 @default.
• W2298796614 hasRelatedWork W2026852955 @default.
• W2298796614 hasRelatedWork W2082668732 @default.
• W2298796614 hasRelatedWork W2142867416 @default.
• W2298796614 hasRelatedWork W2170156818 @default.
• W2298796614 hasRelatedWork W2368193018 @default.

• next