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- W2298843160 abstract "The purpose of this study was to investigate possible effects of organochlorine residues on hormonal adaptability in a freshwater fish. The combined stress of netting, handling and blood sampling in S. aureus normally results in a twofold increase of circulating cortisol within 30–60 min Fish contaminated with o,p′DDD had higher resting level of cortisol than before contamination (155.8 ± 12.7 vs. 86.9 ± 11.2 ng/ml; n = 16). No increase in cortisol level occurred, however, in these fish after exposure to stress. The inability to respond to the stress was maintained for more than 120 days. Since circulating levels of cortisol reflect the equilibrium between secretion and metabolic clearance rates, the effect at the site of cortisol secretion and the site of cortisol metabolism were examined separately. Using a superfusion technique it was possible to demonstrate that organochlorines such as o,p′DDD or DDE suppress cortisol output in response to ACTH. The suppression results from an interference with the production of cAMP in the interrenal tissue. Successive blood sampling of contaminated fish injected intracardially with labeled cortisol have shown that the half-life of the steroid in the circulation is prolonged by 400% as compared with untreated controls (t1/2 = 216 vs. 58 min, respectively). The hepatic metabolism of cortisol was studied by incubating liver slices with the labeled hormone. Hepatic tissue from o,p’DDD-treated fish metabolized cortisol much slower than livers from untreated controls (t1/2 = 155 vs. t1/2 = 85 min) The high resting level of cortisol in plasma of fish contaminated with o,p′DDD is attributed to the retarded metabolism of the steroid by the liver. The lack of augmented cortisol level in response to stress is attributed to the interference of the organochlorine with the response of the interrenal tissue to the endogenous surge of ACTH." @default.
- W2298843160 created "2016-06-24" @default.
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- W2298843160 date "1983-01-01" @default.
- W2298843160 modified "2023-09-24" @default.
- W2298843160 title "Interrenal Activity and Cortisol Metabolism in Organochlorine-Contaminated Fish (Sarotherodon aureus)" @default.
- W2298843160 doi "https://doi.org/10.1007/978-3-642-69083-9_36" @default.
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