Matches in SemOpenAlex for { <https://semopenalex.org/work/W2298847400> ?p ?o ?g. }
- W2298847400 abstract "Significance C/D box small nucleolar RNAs (SNORDs) are abundant, short, nucleoli-residing, noncoding RNAs that guide the methyltransferase fibrillarin to perform 2′- O -methylation of target RNAs. We identified 29 SNORDs present in a fibrillarin-containing fraction as well as a fibrillarin-free fraction enriched in spliceosomes. One of these SNORDs, SNORD27 , directs rRNA methylation and regulates alternative pre-mRNA splicing (AS) of E2F7 pre-mRNA, a transcriptional repressor of cell cycle-regulated genes. SNORD27 likely regulates E2F7 pre-mRNA AS by masking splice sites through base pairing. This previously unidentified function of SNORDs increases the number of factors regulating AS, a critical step in the expression of the vast majority of human genes, and highlights a potential coupling between AS, cell cycle, proliferation, and ribosome biogenesis." @default.
- W2298847400 created "2016-06-24" @default.
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- W2298847400 date "2016-03-08" @default.
- W2298847400 modified "2023-10-10" @default.
- W2298847400 title "Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing" @default.
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- W2298847400 doi "https://doi.org/10.1073/pnas.1519292113" @default.
- W2298847400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4812717" @default.